Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP303 |
Early-Life Exposure to Perfluoroalkyl Substances and Childhood Metabolic Function | |
Fleisch, Abby F.1; Rifas-Shiman, Sheryl L.2,3; Mora, Ana M.4,5; Calafat, Antonia M.; Ye, Xiaoyun; Luttmann-Gibson, Heike7; Gillman, Matthew W.2,3,8; Oken, Emily2,3,8; Sagiv, Sharon K.9 | |
2017-03-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:3 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Costa Rica |
英文摘要 | Background: Perfluoroalkyl substances (PFASs) are synthetic chemicals that may persist in the environment and in humans. There is a possible association between early-life PFAS exposure and metabolic dysfunction in later life, but data are limited. Methods: We studied 665 mother-child pairs in Project Viva, a Boston, Massachusetts-area cohort recruited 1999-2002. We quantified concentrations of PFASs [perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoate (PFNA), perfluorohexane sulfonate (PFHxS), and perfluorodecanoate (PFDeA)] in maternal plasma collected at the first prenatal visit (median, 9.6 weeks gestation) and in child plasma from the mid-childhood research visit (median, 7.7 years). We assessed leptin, adiponectin, and homeostatic model assessment of insulin resistance (HOMA-IR) in mid-childhood. We fit covariate-adjusted linear regression models and conducted stratified analyses by child sex. Results: Children with higher PFAS concentrations had lower HOMA-IR [e.g., -10.1% (95% CI: -17.3, -2.3) per interquartile range increment in PFOA]. This inverse association between child PFAS and HOMA-IR was more pronounced in females [e.g., PFOA: -15.6% (95% CI: -25.4, -4.6) vs. -6.1% (95% CI: -16.2, 5.2) for males]. Child PFAS plasma concentrations were not associated with leptin or adiponectin. Prenatal PFAS plasma concentrations were not associated with leptin, adiponectin, or HOMA-IR in offspring. Conclusions: We found no evidence for an adverse effect of early-life PFAS exposure on metabolic function in mid-childhood. In fact, children with higher PFAS concentrations had lower insulin resistance. |
领域 | 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000395714400032 |
WOS关键词 | PERFLUOROOCTANE SULFONATE PFOS ; NUTRITION-EXAMINATION-SURVEY ; POLYFLUOROALKYL CHEMICALS ; PERFLUORINATED COMPOUNDS ; NATIONAL-HEALTH ; ACID PFOA ; CHILDREN ; ASSOCIATION ; GENE ; AGE |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22225 |
专题 | 资源环境科学 |
作者单位 | 1.Boston Childrens Hosp, Div Endocrinol, Boston, MA USA; 2.Harvard Med Sch, Dept Populat Med, Obes Prevent Program, Boston, MA USA; 3.Harvard Pilgrim Hlth Care Inst, Boston, MA USA; 4.Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA; 5.Univ Nacl, Cent Amer Inst Studies Toxic Subst IRET, Heredia, Costa Rica; 6.Ctr Dis Control & Prevent, Div Lab Sci, Natl Ctr Environm Hlth, Atlanta, GA USA; 7.Harvard Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA; 8.Harvard Sch Publ Hlth, Dept Nutr, Boston, MA USA; 9.Univ Calif Berkeley, Sch Publ Hlth, CERCH, Berkeley, CA 94720 USA |
推荐引用方式 GB/T 7714 | Fleisch, Abby F.,Rifas-Shiman, Sheryl L.,Mora, Ana M.,et al. Early-Life Exposure to Perfluoroalkyl Substances and Childhood Metabolic Function[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(3). |
APA | Fleisch, Abby F..,Rifas-Shiman, Sheryl L..,Mora, Ana M..,Calafat, Antonia M..,Ye, Xiaoyun.,...&Sagiv, Sharon K..(2017).Early-Life Exposure to Perfluoroalkyl Substances and Childhood Metabolic Function.ENVIRONMENTAL HEALTH PERSPECTIVES,125(3). |
MLA | Fleisch, Abby F.,et al."Early-Life Exposure to Perfluoroalkyl Substances and Childhood Metabolic Function".ENVIRONMENTAL HEALTH PERSPECTIVES 125.3(2017). |
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