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DOI | 10.1038/s41467-019-12404-1 |
Cancer exosomes induce tumor innervation | |
Madeo, Marianna1; Colbert, Paul L.1; Vermeer, Daniel W.1; Lucido, Christopher T.1; Cain, Jacob T.2; Vichaya, Elisabeth G.3; Grossberg, Aaron J.3,4; Muirhead, DesiRae5; Rickel, Alex P.6; Hong, Zhongkui6; Zhao, Jing7; Weimer, Jill M.2; Spanos, William C.1,8; Lee, John H.9; Dantzer, Robert3; Vermeer, Paola D.1 | |
2019-09-27 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Patients with densely innervated tumors suffer with increased metastasis and decreased survival as compared to those with less innervated tumors. We hypothesize that in some tumors, nerves are acquired by a tumor-induced process, called axonogenesis. Here, we use PC12 cells as an in vitro neuronal model, human tumor samples and murine in vivo models to test this hypothesis. When appropriately stimulated, PC12 cells extend processes, called neurites. We show that patient tumors release vesicles, called exosomes, which induce PC12 neurite outgrowth. Using a cancer mouse model, we show that tumors compromised in exosome release are less innervated than controls. Moreover, in vivo pharmacological blockade of exosome release similarly attenuates tumor innervation. We characterize these nerves as sensory in nature and demonstrate that axonogenesis is potentiated by the exosome-packaged axonal guidance molecule, EphrinB1. These findings indicate that tumor released exosomes induce tumor innervation and exosomes containing EphrinB1 potentiate this activity. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000447361400003 |
WOS关键词 | NERVE GROWTH-FACTOR ; PANCREATIC DUCTAL ADENOCARCINOMA ; HUMAN-PAPILLOMAVIRUS TYPE-16 ; SIGNAL-REGULATED KINASE ; PDZ-BINDING MOTIF ; EXTRACELLULAR VESICLES ; SUSTAINED ACTIVATION ; CONE COLLAPSE ; EPH RECEPTORS ; EXPRESSION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204567 |
专题 | 资源环境科学 |
作者单位 | 1.Sanford Res, Canc Biol & Immunotherapies Grp, 2301 East 60th St North, Sioux Falls, SD 57104 USA; 2.Sanford Res, Pediat & Rare Dis Grp, 2301 East 60th St North, Sioux Falls, SD 57104 USA; 3.MD Anderson Canc Ctr, Dept Symptom Res, 1515 Holcombe Blvd,Unit 384, Houston, TX 77030 USA; 4.Oregon Hlth & Sci Univ, Canc Early Detect Adv Res Ctr, Dept Radiat Med, 2720 SW Moody Ave KR CEDR, Portland, OR 97201 USA; 5.Sanford Hlth, Sanford Hlth Pathol Clin, 1305 West 18th St, Sioux Falls, SD 57105 USA; 6.Univ South Dakota, Biomed Engn Program, 4800 North Career Ave, Sioux Falls, SD 57107 USA; 7.Sanford Res, Populat Hlth Grp, 2301 East 60th St North, Sioux Falls, SD 57104 USA; 8.Sanford Ears Nose & Throat, 1310 West 22nd St, Sioux Falls, SD 57105 USA; 9.NantKwest, 9920 Jefferson Blvd, Culver City, CA 90232 USA |
推荐引用方式 GB/T 7714 | Madeo, Marianna,Colbert, Paul L.,Vermeer, Daniel W.,et al. Cancer exosomes induce tumor innervation[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Madeo, Marianna.,Colbert, Paul L..,Vermeer, Daniel W..,Lucido, Christopher T..,Cain, Jacob T..,...&Vermeer, Paola D..(2019).Cancer exosomes induce tumor innervation.NATURE COMMUNICATIONS,9. |
MLA | Madeo, Marianna,et al."Cancer exosomes induce tumor innervation".NATURE COMMUNICATIONS 9(2019). |
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