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DOI | 10.1038/s41467-019-11750-4 |
JunB regulates homeostasis and suppressive functions of effector regulatory T cells | |
Koizumi, Shin-ichi1; Sasaki, Daiki1; Hsieh, Tsung-Han1; Taira, Naoyuki1; Arakaki, Nana2; Yamasaki, Shinichi2; Wang, Ke1; Sarkar, Shukla1; Shirahata, Hiroki1; Miyagi, Mio1; Ishikawa, Hiroki1 | |
2019-08-23 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Japan |
英文摘要 | Foxp3-expressing CD4(+) regulatory T (Treg) cells need to differentiate into effector Treg (eTreg) cells to maintain immune homeostasis. T-cell receptor (TCR)-dependent induction of the transcription factor IRF4 is essential for eTreg differentiation, but how IRF4 activity is regulated in Treg cells is still unclear. Here we show that the AP-1 transcription factor, JunB, is expressed in eTreg cells and promotes an IRF4-dependent transcription program. Mice lacking JunB in Treg cells develop multi-organ autoimmunity, concomitant with aberrant activation of T helper cells. JunB promotes expression of Treg effector molecules, such as ICOS and CTLA4, in BATF-dependent and BATF-independent manners, and is also required for homeostasis and suppressive functions of eTreg. Mechanistically, JunB facilitates the accumulation of IRF4 at a subset of IRF4 target sites, including those located near Icos and Ctla4. Thus, JunB is a critical regulator of IRF4-dependent Treg effector programs, high-lighting important functions for AP-1 in Treg-mediated immune homeostasis. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000453441300012 |
WOS关键词 | TRANSCRIPTION-FACTOR ; DIFFERENTIATION ; BATF ; FOXP3(+) ; REQUIREMENT ; PROGRAM ; IRF4 ; ACCUMULATION ; MAINTENANCE ; CHECKPOINT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204510 |
专题 | 资源环境科学 |
作者单位 | 1.Grad Univ, Okinawa Inst Sci & Technol, Immune Signal Unit, 1919-1 Tancha, Onna Son, Okinawa 9040495, Japan; 2.Grad Univ, Okinawa Inst Sci & Technol, DNA Sequencing Sect, 1919-1 Tancha, Onna Son, Okinawa 9040495, Japan |
推荐引用方式 GB/T 7714 | Koizumi, Shin-ichi,Sasaki, Daiki,Hsieh, Tsung-Han,et al. JunB regulates homeostasis and suppressive functions of effector regulatory T cells[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Koizumi, Shin-ichi.,Sasaki, Daiki.,Hsieh, Tsung-Han.,Taira, Naoyuki.,Arakaki, Nana.,...&Ishikawa, Hiroki.(2019).JunB regulates homeostasis and suppressive functions of effector regulatory T cells.NATURE COMMUNICATIONS,9. |
MLA | Koizumi, Shin-ichi,et al."JunB regulates homeostasis and suppressive functions of effector regulatory T cells".NATURE COMMUNICATIONS 9(2019). |
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