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DOI | 10.1038/s41467-019-11314-6 |
Foxn1-beta 5t transcriptional axis controls CD8(+) T-cell production in the thymus | |
Uddin, Muhammad Myn1; Ohigashi, Izumi1; Motosugi, Ryo2; Nakayama, Tomomi2; Sakata, Mie1; Hamazaki, Jun2; Nishito, Yasumasa3; Rode, Immanuel4; Tanaka, Keiji5; Takemoto, Tatsuya6; Murata, Shigeo2; Takahama, Yousuke1 | |
2019-07-29 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Japan; Germany |
英文摘要 | The thymus is an organ that produces functionally competent T cells that protect us from pathogens and malignancies. Foxn1 is a transcription factor that is essential for thymus organogenesis; however, the direct target for Foxn1 to actuate thymic T-cell production is unknown. Here we show that a Foxn1-binding cis-regulatory element promotes the transcription of beta 5t, which has an essential role in cortical thymic epithelial cells to induce positive selection of functionally competent CD8(+) T cells. A point mutation in this genome element results in a defect in beta 5t expression and CD8(+) T-cell production in mice. The results reveal a Foxn1-beta 5t transcriptional axis that governs CD8(+) T-cell production in the thymus. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000393458500001 |
WOS关键词 | POSITIVE SELECTION ; FOXN1 ; EXPRESSION ; PROTEIN ; GENE ; REPERTOIRE ; TARGET |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204467 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Tokushima, Inst Adv Med Sci, Div Expt Immunol, Tokushima 7708503, Japan; 2.Univ Tokyo, Grad Sch Pharmaceut Sci, Lab Prot Metab, Tokyo 1130033, Japan; 3.Tokyo Metropolitan Inst Med Sci, Core Technol & Res Ctr, Tokyo 1568506, Japan; 4.German Canc Res Ctr, Div Cellular Immunol, D-69120 Heidelberg, Germany; 5.Tokyo Metropolitan Inst Med Sci, Lab Prot Metab, Tokyo 1568506, Japan; 6.Univ Tokushima, Inst Adv Med Sci, Lab Embryol, Tokushima 7708503, Japan |
推荐引用方式 GB/T 7714 | Uddin, Muhammad Myn,Ohigashi, Izumi,Motosugi, Ryo,et al. Foxn1-beta 5t transcriptional axis controls CD8(+) T-cell production in the thymus[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Uddin, Muhammad Myn.,Ohigashi, Izumi.,Motosugi, Ryo.,Nakayama, Tomomi.,Sakata, Mie.,...&Takahama, Yousuke.(2019).Foxn1-beta 5t transcriptional axis controls CD8(+) T-cell production in the thymus.NATURE COMMUNICATIONS,8. |
MLA | Uddin, Muhammad Myn,et al."Foxn1-beta 5t transcriptional axis controls CD8(+) T-cell production in the thymus".NATURE COMMUNICATIONS 8(2019). |
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