CD40-signalling abrogates induction of ROR gamma t(+) Treg cells by intestinal CD103(+) DCs and causes fatal colitis

doi:10.1038/s41467-019-08401-z

GSTDTAP > 资源环境科学

DOI	10.1038/s41467-019-08401-z
	CD40-signalling abrogates induction of ROR gamma t(+) Treg cells by intestinal CD103(+) DCs and causes fatal colitis
	Barthels, Christian 1; Ogrinc, Ana 1; Steyer, Verena 1; Meier, Stefanie 1; Simon, Ferdinand 1; Wimmer, Maria 2,3; Blutke, Andreas 4; Straub, Tobias 5; Zimber-Strobl, Ursula 6; Lutgens, Esther 7,8; Marconi, Peggy 9; Ohnmacht, Caspar 2,3; Garzetti, Debora 10; Stecher, Baerbel 10; Brocker, Thomas 1
	2019-02-08
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
出版年	2017
卷号	8
文章类型	Article
语种	英语
国家	Germany; Netherlands; Italy
英文摘要	Immune homeostasis in intestinal tissues depends on the generation of regulatory T (Treg) cells. CD103(+) dendritic cells (DCs) acquire microbiota-derived material from the gut lumen for transport to draining lymph nodes and generation of receptor-related orphan gamma t(+) (ROR gamma t(+)) Helios(-)-induced Treg (iTreg) cells. Here we show CD40-signalling as a microbe-independent signal that can induce migration of CD103(+) DCs from the lamina propria (LP) to the mesenteric lymph nodes. Transgenic mice with constitutive CD11c-specific CD40-signalling have reduced numbers of CD103(+) DCs in LP and a low frequency of ROR gamma t(+)Helios(-) iTreg cells, exacerbated inflammatory Th1/Th17 responses, high titres of microbiota-specific immunoglobulins, dysbiosis and fatal colitis, but no pathology is detected in other tissues. Our data demonstrate a CD40-dependent mechanism capable of abrogating iTreg cell induction by DCs, and suggest that the CD40L/CD40-signalling axis might be able to intervene in the generation of new iTreg cells in order to counter-regulate immune suppression to enhance immunity.
领域	资源环境
收录类别	SCI-E
WOS记录号	WOS:000395855800001
WOS关键词	REGULATORY T-CELLS ; CLASSICAL DENDRITIC CELLS ; IN-VIVO ; INTEGRIN ALPHA-V-BETA-8 ; SIGNALING CONTROLS ; RETINOIC-ACID ; TH17 CELLS ; REG-CELLS ; B-CELLS ; IMMUNITY
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
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文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/204206
专题	资源环境科学
作者单位	1.Ludwig Maximilians Univ Munchen, Inst Immunol, Grosshaderner Str 9, D-82152 Planegg Martinsried, Germany; 2.Helmholtz Ctr, Ctr Allergy Environm ZAUM, D-85764 Neuherberg, Germany; 3.Tech Univ Munich, D-85764 Neuherberg, Germany; 4.Ludwig Maximilians Univ Munchen, Sect Anim Pathol, Dept Vet Clin Sci, D-80539 Munich, Germany; 5.Ludwig Maximilians Univ Munchen, BMC, Bioinformat Core Unit, Grosshaderner Str 9, D-82152 Planegg Munich, Germany; 6.Helmholtz Zentrum Munchen, Res Unit Gene Vectors, D-81377 Munich, Germany; 7.Ludwig Maximilians Univ Munchen, Inst Prophylaxe & Epidemiol Kreislaufkrankheiten, D-80336 Munich, Germany; 8.AMC, Dept Med Biochem, NL-1105 AZ Amsterdam, Netherlands; 9.Univ Ferrara, Dept Life Sci & Biotechnol, I-44121 Ferrara, Italy; 10.Ludwig Maximilians Univ Munchen, Partner Site Munich, German Ctr Infect Res DZIF, Max von Pettenkofer Inst Hyg & Med Microbiol, D-80336 Munich, Germany
推荐引用方式 GB/T 7714	Barthels, Christian,Ogrinc, Ana,Steyer, Verena,et al. CD40-signalling abrogates induction of ROR gamma t(+) Treg cells by intestinal CD103(+) DCs and causes fatal colitis[J]. NATURE COMMUNICATIONS,2019,8.
APA	Barthels, Christian.,Ogrinc, Ana.,Steyer, Verena.,Meier, Stefanie.,Simon, Ferdinand.,...&Brocker, Thomas.(2019).CD40-signalling abrogates induction of ROR gamma t(+) Treg cells by intestinal CD103(+) DCs and causes fatal colitis.NATURE COMMUNICATIONS,8.
MLA	Barthels, Christian,et al."CD40-signalling abrogates induction of ROR gamma t(+) Treg cells by intestinal CD103(+) DCs and causes fatal colitis".NATURE COMMUNICATIONS 8(2019).