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DOI | 10.1038/s41467-019-08307-w |
Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction | |
Paatero, Ilkka1,2,3; Sauteur, Loic1; Lee, Minkyoung1; Lagendijk, Anne K.4; Heutschi, Daniel1; Wiesner, Cora1; Guzman, Camilo4; Bieli, Dimitri1; Hogan, Benjamin M.4; Affolter, Markus1; Belting, Heinz-Georg1 | |
2019-01-25 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland; Finland; Australia |
英文摘要 | Angiogenesis and vascular remodeling are driven by extensive endothelial cell movements. Here, we present in vivo evidence that endothelial cell movements are associated with oscillating lamellipodia-like structures, which emerge from cell junctions in the direction of cell movements. High-resolution time-lapse imaging of these junction-based lamellipodia (JBL) shows dynamic and distinct deployment of junctional proteins, such as F-actin, VE-cadherin and ZO1, during JBL oscillations. Upon initiation, F-actin and VE-cadherin are broadly distributed within JBL, whereas ZO1 remains at cell junctions. Subsequently, a new junction is formed at the front of the JBL, which then merges with the proximal junction. Rac1 inhibition interferes with JBL oscillations and disrupts cell elongation-similar to a truncation in ve-cadherin preventing VE-cad/F-actin interaction. Taken together, our observations suggest an oscillating ratchet-like mechanism, which is used by endothelial cells to move over each other and thus provides the physical means for cell rearrangements. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000443221800001 |
WOS关键词 | ADHERENS JUNCTIONS ; ZEBRAFISH EMBRYO ; VESSEL FUSION ; ANGIOGENESIS ; MORPHOGENESIS ; MIGRATION ; DYNAMICS ; POLYMERIZATION ; MECHANISMS ; INTEGRITY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204186 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Basel, Dept Cell Biol, Biozentrum, CH-4056 Basel, Switzerland; 2.Univ Turku, Turku Ctr Biotechnol, FIN-20520 Turku, Finland; 3.Abo Akad Univ, FIN-20520 Turku, Finland; 4.Univ Queensland, Inst Mol Biosci, Div Genom Dev & Dis, St Lucia, Qld 4072, Australia |
推荐引用方式 GB/T 7714 | Paatero, Ilkka,Sauteur, Loic,Lee, Minkyoung,et al. Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Paatero, Ilkka.,Sauteur, Loic.,Lee, Minkyoung.,Lagendijk, Anne K..,Heutschi, Daniel.,...&Belting, Heinz-Georg.(2019).Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction.NATURE COMMUNICATIONS,9. |
MLA | Paatero, Ilkka,et al."Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction".NATURE COMMUNICATIONS 9(2019). |
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