Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo

doi:10.1038/s41467-018-07557-4

GSTDTAP > 资源环境科学

DOI	10.1038/s41467-018-07557-4
	Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo
	Derby, Nina 1; 39;Keefe, Barry R.2
	2018-09-24
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
出版年	2018
卷号	9
文章类型	Article
语种	英语
国家	USA
英文摘要	Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) strategies with proven in vivo efficacy rely on antiretroviral drugs, creating the potential for drug resistance and complicated treatment options in individuals who become infected. Moreover, on-demand products are currently missing from the PrEP development portfolio. Griffithsin (GRFT) is a non-antiretroviral HIV entry inhibitor derived from red algae with an excellent safety profile and potent activity in vitro. When combined with carrageenan (CG), GRFT has strong activity against herpes simplex virus-2 (HSV-2) and human papillomavirus (HPV) in vitro and in vivo. Here, we report that GRFT/CG in a freeze-dried fast dissolving insert (FDI) formulation for on-demand use protects rhesus macaques from a high dose vaginal SHIV SF162P3 challenge 4 h after FDI insertion. Furthermore, the GRFT/CG FDI also protects mice vaginally against HSV-2 and HPV pseudovirus. As a safe, potent, broad-spectrum, on-demand non-antiretroviral product, the GRFT/CG FDI warrants clinical development.
领域	资源环境
收录类别	SCI-E
WOS记录号	WOS:000445329000016
WOS关键词	HERPES-SIMPLEX-VIRUS ; HUMAN-PAPILLOMAVIRUS ; CYANOVIRIN-N ; PREEXPOSURE PROPHYLAXIS ; VAGINAL TRANSMISSION ; INTRAVAGINAL RINGS ; RHESUS MACAQUES ; AFRICAN WOMEN ; HIV-INFECTION ; RT INFECTION
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/204124
专题	资源环境科学
作者单位	1.Populat Council, Ctr Biomed Res, 1230 York Ave, New York, NY 10065 USA; 2.PATH, 2201 Westlake Ave,Suite 200, Seattle, WA 98121 USA; 3.Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, AIDS & Canc Virus Program, 8560 Progress Dr, Frederick, MD 21701 USA; 4.MPI Res, 54943 N Main St, Mattawan, MI 49071 USA; 5.Ctr Dis Control, 1600 Clifton Rd, Atlanta, GA 30333 USA; 6.NCI, Ctr Canc Res, Mol Targets Program, Bldg 560,Room 21-105, Frederick, MD 21702 USA; 7.NCI, Nat Prod Branch, Dev Therapeut Program, Div Canc Treatment & Diag, Bldg 560,Room 21-105, Frederick, MD 21702 USA; 8.MJR4CONSULTING, New York, NY 10065 USA; 9.Tulane Natl Primate Res Ctr, 18703 Three Rivers Rd, Covington, LA 70433 USA; 10.Aaron Diamond AIDS Res Ctr, 455 1st Ave 7, New York, NY 10016 USA; 11.Borough Manhattan Community Coll, Sci Dept, 199 Chambers St, New York, NY 10007 USA
推荐引用方式 GB/T 7714	Derby, Nina,39;Keefe, Barry R.. Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo[J]. NATURE COMMUNICATIONS,2018,9.
APA	Derby, Nina,&39;Keefe, Barry R..(2018).Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo.NATURE COMMUNICATIONS,9.
MLA	Derby, Nina,et al."Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo".NATURE COMMUNICATIONS 9(2018).