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DOI | 10.1038/s41467-018-07535-w |
Control of transmembrane charge transfer in cytochrome c oxidase by the membrane potential | |
Bjorck, Markus L.; Brzezinski, Peter | |
2018-08-09 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Sweden |
英文摘要 | The respiratory chain in mitochondria is composed of membrane-bound proteins that couple electron transfer to proton translocation across the inner membrane. These charge-transfer reactions are regulated by the proton electrochemical gradient that is generated and maintained by the transmembrane charge transfer. Here, we investigate this feedback mechanism in cytochrome c oxidase in intact inner mitochondrial membranes upon generation of an electrochemical potential by hydrolysis of ATP. The data indicate that a reaction step that involves proton uptake to the catalytic site and presumably proton translocation is impaired by the potential, but electron transfer is not affected. These results define the order of electron and proton-transfer reactions and suggest that the proton pump is regulated by the transmembrane electrochemical gradient through control of internal proton transfer rather than by control of electron transfer. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000441157600022 |
WOS关键词 | CATALYZING OXIDATIVE-PHOSPHORYLATION ; ACTIVE-SITE TYROSINE ; PROTON-TRANSFER ; SUBMITOCHONDRIAL PARTICLES ; ELECTRON-TRANSFER ; PARTIAL RESOLUTION ; OXYGEN REDUCTION ; MECHANISM ; PUMP ; TRANSLOCATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204107 |
专题 | 资源环境科学 |
作者单位 | Stockholm Univ, Dept Biochem & Biophys, Arrhenius Labs Nat Sci, SE-10691 Stockholm, Sweden |
推荐引用方式 GB/T 7714 | Bjorck, Markus L.,Brzezinski, Peter. Control of transmembrane charge transfer in cytochrome c oxidase by the membrane potential[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Bjorck, Markus L.,&Brzezinski, Peter.(2018).Control of transmembrane charge transfer in cytochrome c oxidase by the membrane potential.NATURE COMMUNICATIONS,9. |
MLA | Bjorck, Markus L.,et al."Control of transmembrane charge transfer in cytochrome c oxidase by the membrane potential".NATURE COMMUNICATIONS 9(2018). |
条目包含的文件 | 条目无相关文件。 |
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