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DOI | 10.1038/s41467-018-06779-w |
DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1 | |
Ribeiro-Silva, Cristina1; Aydin, Ozge Z.1,3; Mesquita-Ribeiro, Raquel2; Slyskova, Jana1; Helfricht, Angela1; Marteijn, Jurgen A.1; Hoeijmakers, Jan H. J.1; Lans, Hannes1; Vermeulen, Wim1 | |
2018-10-04 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Netherlands; England; Turkey |
英文摘要 | Mutations in SWI/SNF genes are amongst the most common across all human cancers, but efficient therapeutic approaches that exploit vulnerabilities caused by SWI/SNF mutations are currently lacking. Here, we show that the SWI/SNF ATPases BRM/SMARCA2 and BRG1/SMARCA4 promote the expression of p62/GTF2H1, a core subunit of the transcription factor IIH (TFIIH) complex. Inactivation of either ATPase subunit downregulates GTF2H1 and therefore compromises TFIIH stability and function in transcription and nucleotide excision repair (NER). We also demonstrate that cells with permanent BRM or BRG1 depletion have the ability to restore GTF2H1 expression. As a consequence, the sensitivity of SWI/SNF deficient cells to DNA damage induced by UV irradiation and cisplatin treatment depends on GTF2H1 levels. Together, our results expose GTF2H1 as a potential novel predictive marker of platinum drug sensitivity in SWI/SNF-deficient cancer cells. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000446313800002 |
WOS关键词 | NUCLEOTIDE EXCISION-REPAIR ; TRANSCRIPTION FACTOR IIH ; REMODELING FACTOR BRG1 ; XERODERMA-PIGMENTOSUM ; DOWN-REGULATION ; LUNG-CANCER ; IN-VIVO ; GROUP-C ; CHROMATIN ; COMPLEXES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204091 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Med Ctr Rotterdam, Erasmus MC, Dept Mol Genet, Oncode Inst, Dr Molewaterpl 40, NL-3015 GD Rotterdam, Netherlands; 2.Univ Nottingham, Sch Life Sci, Nottingham NG7 2UH, England; 3.Koc Univ, Mol Biol & Genet Dept, TR-34450 Istanbul, Turkey |
推荐引用方式 GB/T 7714 | Ribeiro-Silva, Cristina,Aydin, Ozge Z.,Mesquita-Ribeiro, Raquel,et al. DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Ribeiro-Silva, Cristina.,Aydin, Ozge Z..,Mesquita-Ribeiro, Raquel.,Slyskova, Jana.,Helfricht, Angela.,...&Vermeulen, Wim.(2018).DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1.NATURE COMMUNICATIONS,9. |
MLA | Ribeiro-Silva, Cristina,et al."DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1".NATURE COMMUNICATIONS 9(2018). |
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