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DOI | 10.1038/s41467-018-06551-0 |
Time-programmable drug dosing allows the manipulation, suppression and reversal of antibiotic drug resistance in vitro | |
Yoshida, Mari1; Reyes, Sabrina Galinanes1; Tsuda, Soichiro1; Horinouchi, Takaaki2; Furusawa, Chikara2,3; Cronin, Leroy1 | |
2017-06-08 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Scotland; Japan |
英文摘要 | Multi-drug strategies have been attempted to prolong the efficacy of existing antibiotics, but with limited success. Here we show that the evolution of multi-drug-resistant Escherichia coli can be manipulated in vitro by administering pairs of antibiotics and switching between them in ON/OFF manner. Using a multiplexed cell culture system, we find that switching between certain combinations of antibiotics completely suppresses the development of resistance to one of the antibiotics. Using this data, we develop a simple deterministic model, which allows us to predict the fate of multi-drug evolution in this system. Furthermore, we are able to reverse established drug resistance based on the model prediction by modulating antibiotic selection stresses. Our results support the idea that the development of antibiotic resistance may be potentially controlled via continuous switching of drugs. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000402867900001 |
WOS关键词 | ESCHERICHIA-COLI STRAINS ; STAPHYLOCOCCUS-AUREUS ; ADAPTIVE EVOLUTION ; ETHANOL STRESS ; DYNAMIC-MODEL ; POWDER DRY ; MUTATIONS ; EXPRESSION ; EMERGENCE ; SELECTION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204022 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Glasgow, Sch Chem, WestCHEM, Glasgow G12 8QQ, Lanark, Scotland; 2.RIKEN, Quantitat Biol Ctr, 6-2-3 Furuedai, Suita, Osaka 5650874, Japan; 3.Univ Tokyo, Dept Phys, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan |
推荐引用方式 GB/T 7714 | Yoshida, Mari,Reyes, Sabrina Galinanes,Tsuda, Soichiro,et al. Time-programmable drug dosing allows the manipulation, suppression and reversal of antibiotic drug resistance in vitro[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Yoshida, Mari,Reyes, Sabrina Galinanes,Tsuda, Soichiro,Horinouchi, Takaaki,Furusawa, Chikara,&Cronin, Leroy.(2017).Time-programmable drug dosing allows the manipulation, suppression and reversal of antibiotic drug resistance in vitro.NATURE COMMUNICATIONS,8. |
MLA | Yoshida, Mari,et al."Time-programmable drug dosing allows the manipulation, suppression and reversal of antibiotic drug resistance in vitro".NATURE COMMUNICATIONS 8(2017). |
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