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DOI | 10.1038/s41467-018-06259-1 |
alpha v integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis | |
Murray, I. R.1,2,3; Gonzalez, Z. N.2,3; Baily, J.2,3; Dobie, R.4; Wallace, R. J.1; Mackinnon, A. C.4; Smith, J. R.4; Greenhalgh, S. N.4; Thompson, A. I.4; Conroy, K. P.4; Griggs, D. W.5; Ruminski, P. G.5; Gray, G. A.6; Singh, M.5; Campbell, M. A.5; Kendall, T. J.4; Dai, J.7,8; Li, Y.7,8; Iredale, J. P.9; Simpson, H.1; Huard, J.10,11; Peault, B.2,3,12,13; Henderson, N. C.4 | |
2017-10-24 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Scotland; USA; England |
英文摘要 | Mesenchymal cells expressing platelet-derived growth factor receptor beta (PDGFR beta) are known to be important in fibrosis of organs such as the liver and kidney. Here we show that PDGFR beta(+) cells contribute to skeletal muscle and cardiac fibrosis via a mechanism that depends on alpha v integrins. Mice in which av integrin is depleted in PDGFR beta(+) cells are protected from cardiotoxin and laceration-induced skeletal muscle fibrosis and angiotensin II-induced cardiac fibrosis. In addition, a small-molecule inhibitor of av integrins attenuates fibrosis, even when pre-established, in both skeletal and cardiac muscle, and improves skeletal muscle function. alpha v integrin blockade also reduces TGF beta activation in primary human skeletal muscle and cardiac PDGFR beta(+) cells, suggesting that av integrin inhibitors may be effective for the treatment and prevention of a broad range of muscle fibroses. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413573000013 |
WOS关键词 | ACTIVATES LATENT TGF-BETA-1 ; TGF-BETA ; FIBRO/ADIPOGENIC PROGENITORS ; INCREASED EXPRESSION ; STEM-CELLS ; INJURY ; DIFFERENTIATION ; FIBROBLASTS ; MOUSE ; ALPHA-V-BETA-5 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204001 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Edinburgh, Dept Trauma & Orthopaed, Chancellors Bldg,Little France Campus, Edinburgh EH16 4TJ, Midlothian, Scotland; 2.Univ Edinburgh, BHF Ctr Vasc Regenerat, 5 Little France Dr, Edinburgh EH16 4UU, Midlothian, Scotland; 3.Univ Edinburgh, MRC, Ctr Regenerat Med, 5 Little France Dr, Edinburgh EH16 4UU, Midlothian, Scotland; 4.Univ Edinburgh, Queens Med Res Inst, MRC, Ctr Inflammat Res, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland; 5.St Louis Univ, Edward A Doisy Res Ctr, Ctr World Hlth & Med, St Louis, MO 63104 USA; 6.Univ Edinburgh, Queens Med Res Inst, BHF Ctr Cardiovasc Sci, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland; 7.Univ Texas Houston, McGovern Med Sch, Dept Pediat Surg, Houston, TX 77030 USA; 8.Univ Texas Hlth Sci Ctr Houston UT Health, Brown Fdn, Inst Mol Med, Ctr Stem Cell & Regenerat Med, Houston, TX 77030 USA; 9.Univ Bristol, Senate House,Tyndall Ave, Bristol BS8 1TH, Avon, England; 10.Steadman Philippon Res Inst, Vail, CO 81657 USA; 11.Univ Texas Houston, Sch Med, Dept Orthopaed Surg, Houston, TX 77030 USA; 12.Univ Calif Los Angeles, Orthopaed Hosp Res Ctr, Los Angeles, CA 90024 USA; 13.Univ Calif Los Angeles, Broad Stem Cell Res Ctr, Los Angeles, CA 90024 USA |
推荐引用方式 GB/T 7714 | Murray, I. R.,Gonzalez, Z. N.,Baily, J.,et al. alpha v integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Murray, I. R..,Gonzalez, Z. N..,Baily, J..,Dobie, R..,Wallace, R. J..,...&Henderson, N. C..(2017).alpha v integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis.NATURE COMMUNICATIONS,8. |
MLA | Murray, I. R.,et al."alpha v integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis".NATURE COMMUNICATIONS 8(2017). |
条目包含的文件 | 条目无相关文件。 |
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