Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-018-06238-6 |
Predicting metabolic adaptation from networks of mutational paths | |
Josephides, Christos; Swain, Peter S. | |
2017-09-25 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Scotland |
英文摘要 | Competition for substrates is a ubiquitous selection pressure faced by microbes, yet intracellular trade-offs can prevent cells from metabolizing every type of available substrate. Adaptive evolution is constrained by these trade-offs, but their consequences for the repeatability and predictability of evolution are unclear. Here we develop an eco-evolutionary model with a metabolic trade-off to generate networks of mutational paths in microbial communities and show that these networks have descriptive and predictive information about the evolution of microbial communities. We find that long-term outcomes, including community collapse, diversity, and cycling, have characteristic evolutionary dynamics that determine the entropy, or repeatability, of mutational paths. Although reliable prediction of evolutionary outcomes from environmental conditions is difficult, graph-theoretic properties of the mutational networks enable accurate prediction even from incomplete observations. In conclusion, we present a novel methodology for analyzing adaptive evolution and report that the dynamics of adaptation are a key variable for predictive success. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000411646700007 |
WOS关键词 | EVOLUTIONARY DYNAMICS ; SUBSTITUTABLE RESOURCES ; COMPETITION ; DIVERSIFICATION ; MAINTENANCE ; SELECTION ; CHAOS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203996 |
专题 | 资源环境科学 |
作者单位 | Univ Edinburgh, Sch Biol Sci, SynthSys Synthet & Syst Biol, Edinburgh EH9 3BF, Midlothian, Scotland |
推荐引用方式 GB/T 7714 | Josephides, Christos,Swain, Peter S.. Predicting metabolic adaptation from networks of mutational paths[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Josephides, Christos,&Swain, Peter S..(2017).Predicting metabolic adaptation from networks of mutational paths.NATURE COMMUNICATIONS,8. |
MLA | Josephides, Christos,et al."Predicting metabolic adaptation from networks of mutational paths".NATURE COMMUNICATIONS 8(2017). |
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