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DOI | 10.1038/s41467-018-06030-6 |
Cell fate in antiviral response arises in the crosstalk of IRF, NF-kappa B and JAK/STAT pathways | |
Czerkies, Maciej1; Korwek, Zbigniew1; Prus, Wiktor1; Kochanczyk, Marek1; Jaruszewicz-Blonska, Joanna1; Tudelska, Karolina1; Blonski, Slawomir1; Kimmel, Marek2,3,4,5; Brasier, Allan R.6; Lipniacki, Tomasz1 | |
2018-02-05 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Poland; USA |
英文摘要 | The innate immune system processes pathogen-induced signals into cell fate decisions. How information is turned to decision remains unknown. By combining stochastic mathematical modelling and experimentation, we demonstrate that feedback interactions between the IRF3, NF-kappa B and STAT pathways lead to switch-like responses to a viral analogue, poly(I:C), in contrast to pulse-like responses to bacterial LPS. Poly(I:C) activates both IRF3 and NF-kappa B, a requirement for induction of IFN beta expression. Autocrine IFN beta initiates a JAK/STAT-mediated positive-feedback stabilising nuclear IRF3 and NF-kappa B in first responder cells. Paracrine IFN beta, in turn, sensitises second responder cells through a JAK/STAT-mediated positive feedforward pathway that upregulates the positive-feedback components:RIG-I, PKR and OAS1A. In these sensitised cells, the 'live-or-die' decision phase following poly(I:C) exposure is shorter-they rapidly produce antiviral responses and commit to apoptosis. The interlinked positive feedback and feedforward signalling is key for coordinating cell fate decisions in cellular populations restricting pathogen spread. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000424091500003 |
WOS关键词 | DOUBLE-STRANDED-RNA ; INDUCIBLE GENE-I ; BETA RESPONSE ; IFN ; EXPRESSION ; ACTIVATION ; DYNAMICS ; RECOGNITION ; SUPPRESSOR ; INDUCTION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203983 |
专题 | 资源环境科学 |
作者单位 | 1.Polish Acad Sci, Inst Fundamental Technol Res, PL-02106 Warsaw, Poland; 2.Rice Univ, Dept Stat, Houston, TX 77005 USA; 3.Rice Univ, Dept Bioengn, Houston, TX 77005 USA; 4.Rice Univ, Program Syst Synthet & Phys Biol, Houston, TX 77005 USA; 5.Silesian Tech Univ, Syst Engn Grp, PL-44100 Gliwice, Poland; 6.Univ Texas Med Branch, Inst Translat Sci, Galveston, TX 77555 USA |
推荐引用方式 GB/T 7714 | Czerkies, Maciej,Korwek, Zbigniew,Prus, Wiktor,et al. Cell fate in antiviral response arises in the crosstalk of IRF, NF-kappa B and JAK/STAT pathways[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Czerkies, Maciej.,Korwek, Zbigniew.,Prus, Wiktor.,Kochanczyk, Marek.,Jaruszewicz-Blonska, Joanna.,...&Lipniacki, Tomasz.(2018).Cell fate in antiviral response arises in the crosstalk of IRF, NF-kappa B and JAK/STAT pathways.NATURE COMMUNICATIONS,9. |
MLA | Czerkies, Maciej,et al."Cell fate in antiviral response arises in the crosstalk of IRF, NF-kappa B and JAK/STAT pathways".NATURE COMMUNICATIONS 9(2018). |
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