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DOI | 10.1038/s41467-018-05814-0 |
Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos | |
Takaoka, Katsuyoshi1,2,3; Nishimura, Hiromi1,2; Hamada, Hiroshi1,2 | |
2017-11-14 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Japan; Germany |
英文摘要 | Anterior-posterior (A-P) polarity of mouse embryos is established by distal visceral endoderm (DVE) at embryonic day (E) 5.5. Lefty1 is expressed first at E3.5 in a subset of epiblast progenitor cells (L1(epi) cells) and then in a subset of primitive endoderm cells (L1(dve) cells) fated to become DVE. Here we studied how prospective DVE cells are selected. Lefty1 expression in L1(epi) and L1(dve) cells depends on Nodal signaling. A cell that experiences the highest level of Nodal signaling begins to express Lefty1 and becomes an L1(epi) cell. Deletion of Lefty1 alone or together with Lefty2 increased the number of prospective DVE cells. Ablation of L1(epi) or L1(dve) cells triggered Lefty1 expression in a subset of remaining cells. Our results suggest that selection of prospective DVE cells is both random and regulated, and that a fixed prepattern for the A-P axis does not exist before the blastocyst stage. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000415124000019 |
WOS关键词 | RIGHT ASYMMETRIC EXPRESSION ; ANTERIOR-POSTERIOR AXIS ; LEFTY-2 ; ANTAGONISTS ; DETERMINES ; POLARITY ; ORIGIN ; CRIPTO ; SYSTEM ; CELLS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203957 |
专题 | 资源环境科学 |
作者单位 | 1.Osaka Univ, Grad Sch Frontier Biosci, Dev Genet Grp, 1-3 Yamada Oka, Suita, Osaka 5650871, Japan; 2.RIKEN Ctr Dev Biol, Chuo Ku, 2-2-3 Minatojima Minamimachi, Kobe, Hyogo 6500047, Japan; 3.Max Planck Inst Biophys Chem, Fassberg 11, D-37077 Gottingen, Germany |
推荐引用方式 GB/T 7714 | Takaoka, Katsuyoshi,Nishimura, Hiromi,Hamada, Hiroshi. Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Takaoka, Katsuyoshi,Nishimura, Hiromi,&Hamada, Hiroshi.(2017).Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos.NATURE COMMUNICATIONS,8. |
MLA | Takaoka, Katsuyoshi,et al."Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos".NATURE COMMUNICATIONS 8(2017). |
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