Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos

doi:10.1038/s41467-018-05814-0

GSTDTAP > 资源环境科学

DOI	10.1038/s41467-018-05814-0
	Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos
	Takaoka, Katsuyoshi 1,2,3; Nishimura, Hiromi 1,2; Hamada, Hiroshi 1,2
	2017-11-14
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
出版年	2017
卷号	8
文章类型	Article
语种	英语
国家	Japan; Germany
英文摘要	Anterior-posterior (A-P) polarity of mouse embryos is established by distal visceral endoderm (DVE) at embryonic day (E) 5.5. Lefty1 is expressed first at E3.5 in a subset of epiblast progenitor cells (L1(epi) cells) and then in a subset of primitive endoderm cells (L1(dve) cells) fated to become DVE. Here we studied how prospective DVE cells are selected. Lefty1 expression in L1(epi) and L1(dve) cells depends on Nodal signaling. A cell that experiences the highest level of Nodal signaling begins to express Lefty1 and becomes an L1(epi) cell. Deletion of Lefty1 alone or together with Lefty2 increased the number of prospective DVE cells. Ablation of L1(epi) or L1(dve) cells triggered Lefty1 expression in a subset of remaining cells. Our results suggest that selection of prospective DVE cells is both random and regulated, and that a fixed prepattern for the A-P axis does not exist before the blastocyst stage.
领域	资源环境
收录类别	SCI-E
WOS记录号	WOS:000415124000019
WOS关键词	RIGHT ASYMMETRIC EXPRESSION ; ANTERIOR-POSTERIOR AXIS ; LEFTY-2 ; ANTAGONISTS ; DETERMINES ; POLARITY ; ORIGIN ; CRIPTO ; SYSTEM ; CELLS
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/203957
专题	资源环境科学
作者单位	1.Osaka Univ, Grad Sch Frontier Biosci, Dev Genet Grp, 1-3 Yamada Oka, Suita, Osaka 5650871, Japan; 2.RIKEN Ctr Dev Biol, Chuo Ku, 2-2-3 Minatojima Minamimachi, Kobe, Hyogo 6500047, Japan; 3.Max Planck Inst Biophys Chem, Fassberg 11, D-37077 Gottingen, Germany
推荐引用方式 GB/T 7714	Takaoka, Katsuyoshi,Nishimura, Hiromi,Hamada, Hiroshi. Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos[J]. NATURE COMMUNICATIONS,2017,8.
APA	Takaoka, Katsuyoshi,Nishimura, Hiromi,&Hamada, Hiroshi.(2017).Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos.NATURE COMMUNICATIONS,8.
MLA	Takaoka, Katsuyoshi,et al."Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos".NATURE COMMUNICATIONS 8(2017).