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DOI | 10.1038/s41467-018-05060-4 |
Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions | |
Qiu, Yongzhi1,2,3,4; Tong, Sheng5; Zhang, Linlin5; Sakurai, Yumiko1,2,3,4; Myers, David R.1,2,3,4; Hong, Lin5; Lam, Wilbur A.1,2,3,4; Bao, Gang5 | |
2017-06-08 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The vascular endothelium presents a major transport barrier to drug delivery by only allowing selective extravasation of solutes and small molecules. Therefore, enhancing drug transport across the endothelial barrier has to rely on leaky vessels arising from disease states such as pathological angiogenesis and inflammatory response. Here we show that the permeability of vascular endothelium can be increased using an external magnetic field to temporarily disrupt endothelial adherens junctions through internalized iron oxide nanoparticles, activating the paracellular transport pathway and facilitating the local extravasation of circulating substances. This approach provides a physically controlled drug delivery method harnessing the biology of endothelial adherens junction and opens a new avenue for drug delivery in a broad range of biomedical research and therapeutic applications. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000402868100001 |
WOS关键词 | IN-VIVO ; SHEAR-STRESS ; NANOPARTICLES ; PERMEABILITY ; BARRIER |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203867 |
专题 | 资源环境科学 |
作者单位 | 1.Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA; 2.Emory Univ, Atlanta, GA 30332 USA; 3.Emory Univ, Aflac Canc & Blood Disorders Ctr Childrens Health, Div Pediat Hematol Oncol, Dept Pediat,Sch Med, Atlanta, GA 30332 USA; 4.Emory Univ, Winship Canc Ctr, Atlanta, GA 30332 USA; 5.Rice Univ, Dept Bioengn, Houston, TX 77005 USA |
推荐引用方式 GB/T 7714 | Qiu, Yongzhi,Tong, Sheng,Zhang, Linlin,et al. Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Qiu, Yongzhi.,Tong, Sheng.,Zhang, Linlin.,Sakurai, Yumiko.,Myers, David R..,...&Bao, Gang.(2017).Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions.NATURE COMMUNICATIONS,8. |
MLA | Qiu, Yongzhi,et al."Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions".NATURE COMMUNICATIONS 8(2017). |
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