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DOI | 10.1038/s41467-018-04057-3 |
Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control | |
Yang, Jin-Yu1; Deng, Xiang-Yu2; Li, Yi-Sheng3,4; Ma, Xian-Cai5; Feng, Jian-Xiong1; Yu, Bing1; Chen, Yang1,7; Luo, Yi-Ling1; Wang, Xi3,8; Chen, Mei-Ling1; Fang, Zhi-Xin1; Zheng, Fu-Xiang5; Li, Yi-Ping5; Zhong, Qian1; Kang, Tie-Bang1; Song, Li-Bing1; Xu, Rui-Hua1; Zeng, Mu-Sheng1; Chen, Wei4,6; Zhang, Hui5; Xie, Wei2; Gao, Song1 | |
2018-03-21 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; Germany; USA |
英文摘要 | Cleavage of transfer (t) RNA and ribosomal (r) RNA are critical and conserved steps of translational control for cells to overcome varied environmental stresses. However, enzymes that are responsible for this event have not been fully identified in high eukaryotes. Here, we report a mammalian tRNA/rRNA-targeting endoribonuclease: SLFN13, a member of the Schlafen family. Structural study reveals a unique pseudo-dimeric U-pillow-shaped architecture of the SLFN13 N'-domain that may clamp base-paired RNAs. SLFN13 is able to digest tRNAs and rRNAs in vitro, and the endonucleolytic cleavage dissevers 11 nucleotides from the 3'-terminus of tRNA at the acceptor stem. The cytoplasmically localised SLFN13 inhibits protein synthesis in 293T cells. Moreover, SLFN13 restricts HIV replication in a nucleolytic activity-dependent manner. According to these observations, we term SLFN13 RNase S13. Our study provides insights into the modulation of translational machinery in high eukaryotes, and sheds light on the functional mechanisms of the Schlafen family. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000427928500006 |
WOS关键词 | CYTOTOXIC RIBONUCLEASE ; MALIGNANT-MELANOMA ; CRYSTAL-STRUCTURE ; CATALYTIC DOMAIN ; OXIDATIVE STRESS ; GROWTH ; FRAGMENTS ; GENE ; INHIBITION ; ANGIOGENIN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203808 |
专题 | 资源环境科学 |
作者单位 | 1.Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Guangdong, Peoples R China; 2.Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510060, Guangdong, Peoples R China; 3.Berlin Inst Med Syst Biol, Lab Funct Genom & Syst Biol, D-13125 Berlin, Germany; 4.Southern Univ Sci & Technol, Dept Biol, Shenzhen 518055, Guangdong, Peoples R China; 5.Sun Yat Sen Univ, Inst Human Virol, Zhongshan Sch Med, Key Lab Trop Dis Control,Minist Educ, Guangzhou 510080, Guangdong, Peoples R China; 6.Southern Univ Sci & Technol, Medi X Inst, SUSTech Acad Adv Interdisciplinary Studies, Shenzhen 518055, Guangdong, Peoples R China; 7.NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA; 8.German Canc Res Ctr, Div Theoret Syst Biol, D-69120 Heidelberg, Germany |
推荐引用方式 GB/T 7714 | Yang, Jin-Yu,Deng, Xiang-Yu,Li, Yi-Sheng,et al. Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Yang, Jin-Yu.,Deng, Xiang-Yu.,Li, Yi-Sheng.,Ma, Xian-Cai.,Feng, Jian-Xiong.,...&Gao, Song.(2018).Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.NATURE COMMUNICATIONS,9. |
MLA | Yang, Jin-Yu,et al."Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control".NATURE COMMUNICATIONS 9(2018). |
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