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DOI | 10.1038/s41467-018-04241-5 |
Quantifying cerebral contributions to pain beyond nociception | |
Woo, Choong-Wan1,2,12,13; Schmidt, Liane3,4; Krishnan, Anjali5; Jepma, Marieke6,7; Roy, Mathieu8; Lindquist, Martin A.9; Atlas, Lauren Y.10,11; Wager, Tor D.1,2 | |
2017-02-14 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; France; Netherlands; Canada; South Korea |
英文摘要 | Cerebral processes contribute to pain beyond the level of nociceptive input and mediate psychological and behavioural influences. However, cerebral contributions beyond nociception are not yet well characterized, leading to a predominant focus on nociception when studying pain and developing interventions. Here we use functional magnetic resonance imaging combined with machine learning to develop a multivariate pattern signature-termed the stimulus intensity independent pain signature-1 (SIIPS1)-that predicts pain above and beyond nociceptive input in four training data sets (Studies 1-4, N = 137). The SIIPS1 includes patterns of activity in nucleus accumbens, lateral prefrontal and parahippocampal cortices, and other regions. In cross-validated analyses of Studies 1-4 and in two independent test data sets (Studies 5-6, N = 46), SIIPS1 responses explain variation in trial-by-trial pain ratings not captured by a previous fMRI-based marker for nociceptive pain. In addition, SIIPS1 responses mediate the pain-modulating effects of three psychological manipulations of expectations and perceived control. The SIIPS1 provides an extensible characterization of cerebral contributions to pain and specific brain targets for interventions. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000393857400001 |
WOS关键词 | NUCLEUS-ACCUMBENS ; NEUROPATHIC PAIN ; FUNCTIONAL CONNECTIVITY ; PHYSICAL PAIN ; BACK-PAIN ; PREFRONTAL CORTEX ; BRAIN MEDIATORS ; BASAL GANGLIA ; FMRI ; MECHANISMS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203804 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA; 2.Univ Colorado, Inst Cognit Sci, Boulder, CO 80309 USA; 3.INSEAD, F-77300 Fontainebleau, France; 4.Ecole Normale Super, INSERM U960, Dept Cognit Sci, Cognit Neurosci Lab, F-75005 Paris, France; 5.CUNY Brooklyn Coll, Dept Psychol, Brooklyn, NY 11210 USA; 6.Leiden Univ, Inst Psychol, Cognit Psychol Unit, NL-2300 Leiden, Netherlands; 7.Leiden Univ, Leiden Inst Brain & Cognit, NL-2300 Leiden, Netherlands; 8.McGill Univ, Dept Psychol, Montreal, PQ H3A 0G4, Canada; 9.Johns Hopkins Univ, Dept Biostat, Baltimore, MD 21211 USA; 10.NIH, Natl Ctr Complementary & Integrat Hlth, Bethesda, MD 20892 USA; 11.NIDA, NIH, Rockville, MD 20852 USA; 12.Inst Basic Sci, Ctr Neurosci Imaging Res, Suwon 16419, South Korea; 13.Sungkyunkwan Univ, Dept Biomed Engn, Suwon 16419, South Korea |
推荐引用方式 GB/T 7714 | Woo, Choong-Wan,Schmidt, Liane,Krishnan, Anjali,et al. Quantifying cerebral contributions to pain beyond nociception[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Woo, Choong-Wan.,Schmidt, Liane.,Krishnan, Anjali.,Jepma, Marieke.,Roy, Mathieu.,...&Wager, Tor D..(2017).Quantifying cerebral contributions to pain beyond nociception.NATURE COMMUNICATIONS,8. |
MLA | Woo, Choong-Wan,et al."Quantifying cerebral contributions to pain beyond nociception".NATURE COMMUNICATIONS 8(2017). |
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