Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-018-03180-5 |
Programmed biomolecule delivery to enable and direct cell migration for connective tissue repair | |
Qu, Feini1,2,3; Holloway, Julianne L.2,3; Esterhai, John L.2; Burdick, Jason A.2,3; Mauck, Robert L.1,2,3 | |
2017-11-24 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Dense connective tissue injuries have limited repair, due to the paucity of cells at the wound site. We hypothesize that decreasing the density of the local extracellular matrix (ECM) in conjunction with releasing chemoattractive signals increases cellularity and tissue formation after injury. Using the knee meniscus as a model system, we query interstitial cell migration in the context of migratory barriers using a novel tissue Boyden chamber and show that a gradient of platelet-derived growth factor-AB (PDGF-AB) expedites migration through native tissue. To implement these signals in situ, we develop nanofibrous scaffolds with distinct fiber fractions that sequentially release active collagenase (to increase ECM porosity) and PDGF-AB (to attract endogenous cells) in a localized and coordinated manner. We show that, when placed into a meniscal defect, the controlled release of collagenase and PDGF-AB increases cellularity at the interface and within the scaffold, as well as integration with the surrounding tissue. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000416292800014 |
WOS关键词 | MESENCHYMAL STEM-CELLS ; GROWTH-FACTOR DELIVERY ; IN-VITRO ; ELECTROSPUN NANOFIBERS ; MENISCUS INTEGRATION ; DEFECT MODEL ; REGENERATION ; LIGAMENT ; MATURATION ; SCAFFOLDS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203709 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Penn, Perelman Sch Med, Dept Orthopaed Surg, McKay Orthopaed Res Lab, Philadelphia, PA 19104 USA; 2.Corporal Michael Crescenz VA Med Ctr, Translat Musculoskeletal Res Ctr, Philadelphia, PA 19104 USA; 3.Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA |
推荐引用方式 GB/T 7714 | Qu, Feini,Holloway, Julianne L.,Esterhai, John L.,et al. Programmed biomolecule delivery to enable and direct cell migration for connective tissue repair[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Qu, Feini,Holloway, Julianne L.,Esterhai, John L.,Burdick, Jason A.,&Mauck, Robert L..(2017).Programmed biomolecule delivery to enable and direct cell migration for connective tissue repair.NATURE COMMUNICATIONS,8. |
MLA | Qu, Feini,et al."Programmed biomolecule delivery to enable and direct cell migration for connective tissue repair".NATURE COMMUNICATIONS 8(2017). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论