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DOI | 10.1038/s41467-018-02974-x |
A plant Bro1 domain protein BRAF regulates multivesicular body biogenesis and membrane protein homeostasis | |
Shen, Jinbo1,5; Zhao, Qiong1; Wang, Xiangfeng1,2; Gao, Caiji1,3; Zhu, Ying1; Zeng, Yonglun1; Jiang, Liwen1,4 | |
2018-09-17 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | Plant development, defense, and many physiological processes rely on the endosomal sorting complex required for transport (ESCRT) machinery to control the homeostasis of membrane proteins by selective vacuolar degradation. Although ESCRT core components are conserved among higher eukaryotes, the regulators that control the function of the ESCRT machinery remain elusive. We recently identified a plant-specific ESCRT component, FREE1, that is essential for multivesicular body/prevacuolar compartment (MVB/PVC) biogenesis and vacuolar sorting of membrane proteins. Here we identify a plant-specific Bro1-domain protein BRAF, which regulates FREE1 recruitment to the MVB/PVC membrane by competitively binding to the ESCRT-I component Vps23. Altogether, we have successfully identified a role for BRAF, whose function as a unique evolutionary ESCRT regulator in orchestrating intraluminal vesicle formation in MVB/PVCs and the sorting of membrane proteins for degradation in plants makes it an important regulatory mechanism underlying the ESCRT machinery in higher eukaryotes. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000444757900002 |
WOS关键词 | FLUORESCENT FUSION PROTEINS ; ARABIDOPSIS-THALIANA ; ESCRT COMPONENT ; PREVACUOLAR COMPARTMENTS ; ENDOPLASMIC-RETICULUM ; S-ACYLATION ; TRAFFICKING ; COMPLEX ; TRANSPORT ; PATHWAY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203649 |
专题 | 资源环境科学 |
作者单位 | 1.Chinese Univ Hong Kong, Sch Life Sci, State Key Lab Agrobiotechnol, Ctr Cell & Dev Biol, Shatin, Hong Kong, Peoples R China; 2.China Agr Univ, Coll Biol Sci, Dept Plant Sci, State Key Lab Plant Physiol & Biochem, Beijing 100193, Peoples R China; 3.SCNU, Sch Life Sci, Guangdong Prov Key Lab Biotechnol Plant Dev, Guangzhou 510631, Guangdong, Peoples R China; 4.Chinese Univ Hong Kong, CUHK Shenzhen Res Inst, Shenzhen 518057, Peoples R China; 5.Zhejiang A&F Univ, State Key Lab Subtrop Silviculture, Hangzhou 311300, Zhejiang, Peoples R China |
推荐引用方式 GB/T 7714 | Shen, Jinbo,Zhao, Qiong,Wang, Xiangfeng,et al. A plant Bro1 domain protein BRAF regulates multivesicular body biogenesis and membrane protein homeostasis[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Shen, Jinbo.,Zhao, Qiong.,Wang, Xiangfeng.,Gao, Caiji.,Zhu, Ying.,...&Jiang, Liwen.(2018).A plant Bro1 domain protein BRAF regulates multivesicular body biogenesis and membrane protein homeostasis.NATURE COMMUNICATIONS,9. |
MLA | Shen, Jinbo,et al."A plant Bro1 domain protein BRAF regulates multivesicular body biogenesis and membrane protein homeostasis".NATURE COMMUNICATIONS 9(2018). |
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