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DOI | 10.1038/s41467-017-01820-w |
Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5(-/-) mice | |
Li, Yan1; 39;ev A.2 | |
2019-04-02 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Israel; England; Switzerland |
英文摘要 | Accumulating evidence points to an important role for the gut microbiome in anti-tumor immunity. Here, we show that altered intestinal microbiota contributes to anti-tumor immunity, limiting tumor expansion. Mice lacking the ubiquitin ligase RNF5 exhibit attenuated activation of the unfolded protein response (UPR) components, which coincides with increased expression of inflammasome components, recruitment and activation of dendritic cells and reduced expression of antimicrobial peptides in intestinal epithelial cells. Reduced UPR expression is also seen in murine and human melanoma tumor specimens that responded to immune checkpoint therapy. Co-housing of Rnf5(-/-) and WT mice abolishes the anti-tumor immunity and tumor inhibition phenotype, whereas transfer of 11 bacterial strains, including B. rodentium, enriched in Rnf5(-/-) mice, establishes anti-tumor immunity and restricts melanoma growth in germ-free WT mice. Altered UPR signaling, exemplified in Rnf5(-/-) mice, coincides with altered gut microbiota composition and anti-tumor immunity to control melanoma growth. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000462985600010 |
WOS关键词 | RETICULUM-ASSOCIATED DEGRADATION ; DENDRITIC CELLS ; ER STRESS ; INTESTINAL INFLAMMATION ; ACTIVATION ; PROTEIN ; RNF5 ; EXPRESSION ; INDUCTION ; SURVIVAL |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203551 |
专题 | 资源环境科学 |
作者单位 | 1.Sanford Burnham Prebys Med Discovery Inst, La Jolla, CA 92037 USA; 2.Univ Nebraska, Dept Food Sci & Technol, Lincoln, NE 68588 USA; 3.Univ Maryland, Ctr Bioinformat & Computat Biol, Dept Comp Sci, College Pk, MD 20742 USA; 4.Tel Aviv Univ, Sch Comp Sci, Tel Aviv, Israel; 5.Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel; 6.NCI, Lab Canc Biol & Genet, Ctr Canc Res, NIH, Bethesda, MD 20892 USA; 7.Technion Israel Inst Technol, Technion Integrated Canc Ctr, Fac Med, IL-31096 Haifa, Israel; 8.Harvard Med Sch, Massachusetts Gen Hosp, Canc Ctr, Div Med Oncol, Boston, MA 02114 USA; 9.Univ Cent Florida, Coll Engn & Comp Sci, Dept Comp Sci, Orlando, FL 32816 USA; 10.BioLegend, San Diego, CA 92121 USA; 11.NCI, Div Canc Epidemiol & Genet, Lab Translat Genom, Bethesda, MD 20892 USA; 12.Technion Fac Med, Dept Dermatol, Rambam Hlth Care Campus, IL-31096 Haifa, Israel; 13.Technion Fac Med, Dept Oncol, Rambam Hlth Care Campus, IL-31096 Haifa, Israel; 14.Yale Univ, Dept Pathol, New Haven, CT USA; 15.Univ Oxford, Ludwig Inst Canc Res, Nuffield Dept Med, Old Rd Campus, Oxford OX3 7DQ, England; 16.Univ Hosp Zurich, Dept Dermatol, CH-8091 Zurich, Switzerland; 17.Univ Zurich, CH-8091 Zurich, Switzerland; 18.Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA; 19.NCI, Canc Data Sci Lab, NIH, Bethesda, MD 20892 USA |
推荐引用方式 GB/T 7714 | Li, Yan,39;ev A.. Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5(-/-) mice[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Li, Yan,&39;ev A..(2019).Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5(-/-) mice.NATURE COMMUNICATIONS,10. |
MLA | Li, Yan,et al."Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5(-/-) mice".NATURE COMMUNICATIONS 10(2019). |
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