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DOI | 10.1038/s41467-017-01789-6 |
Contribution of individual olfactory receptors to odor-induced attractive or aversive behavior in mice | |
Horio, Nao1; Murata, Ken1,2; Yoshikawa, Keiichi1; Yoshihara, Yoshihiro2,3; Touhara, Kazushige1,2,4 | |
2019-01-14 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Japan |
英文摘要 | Odorants are recognized by multiple olfactory receptors (ORs) and induce innate behaviors like attraction or aversion via olfactory system in mice. However, a role of an individual OR is unclear. Muscone is recognized by a few ORs including MOR215-1 and MOR214-3, and attracts male mice. Odor preference tests using MOR215-1 knockout mice revealed that MOR215-1 and other OR(s), possibly including MOR214-3, are involved in the attraction. (Z)-5-tetradecen-1-ol (Z5-14:OH) activates similar to 3 ORs, including Olfr288, and evokes attraction at low levels but aversion at higher levels. Olfr288 knockout mice show no attraction but aversion, suggesting Olfr288 is involved in preference for Z5-14:OH, whereas activation of other low-affinity Z5-14:OH receptors evokes aversion. Each OR appears to send a signal to a neural circuit that possesses distinct valence, leading to a certain behavior. The final output behavior with multiple ORs stimulation is determined by summation (addition or competition) of valences coded by activated ORs. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000455595400032 |
WOS关键词 | GENETIC-VARIATION ; SENSITIVITY ; LIGAND ; SPECIFICITY ; PHEROMONES ; INNATE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203543 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Chem, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1138657, Japan; 2.Univ Tokyo, JST, ERATO Touhara Chemosensory Signal Project, Tokyo 1138657, Japan; 3.RIKEN, Lab Syst Mol Ethol, Ctr Brain Sci, Wako, Saitama 3510198, Japan; 4.Univ Tokyo, Int Res Ctr Neurointelligence WPI IRCN, Inst Adv Study, Tokyo 1130033, Japan |
推荐引用方式 GB/T 7714 | Horio, Nao,Murata, Ken,Yoshikawa, Keiichi,et al. Contribution of individual olfactory receptors to odor-induced attractive or aversive behavior in mice[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Horio, Nao,Murata, Ken,Yoshikawa, Keiichi,Yoshihara, Yoshihiro,&Touhara, Kazushige.(2019).Contribution of individual olfactory receptors to odor-induced attractive or aversive behavior in mice.NATURE COMMUNICATIONS,10. |
MLA | Horio, Nao,et al."Contribution of individual olfactory receptors to odor-induced attractive or aversive behavior in mice".NATURE COMMUNICATIONS 10(2019). |
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