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DOI | 10.1038/s41467-017-01579-0 |
NK cells are activated and primed for skin-homing during acute dengue virus infection in humans | |
Zimmer, Christine L.1; Cornillet, Martin1; Sola-Riera, Carles1; Cheung, Ka-Wai2; Ivarsson, Martin A.1; Lim, Mei Qiu2; Marquardt, Nicole1; Leo, Yee-Sin3,4,5,6; Lye, David Chien3,5,6; Klingstrom, Jonas1; MacAry, Paul A.7,8; Ljunggren, Hans-Gustaf1; Rivino, Laura2,9; Bjorkstrom, Niklas K.1 | |
2019-08-29 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Sweden; Singapore; England |
英文摘要 | Despite animal models showing that natural killer (NK) cells are important players in the early defense against many viral infections, the NK cell response is poorly understood in humans. Here we analyze the phenotype, temporal dynamics, regulation and trafficking of NK cells in a patient cohort with acute dengue virus infection. NK cells are robustly activated and proliferate during the first week after symptom debut. Increased IL-18 levels in plasma and in induced skin blisters of DENV-infected patients, as well as concomitant signaling downstream of the IL-18R, suggests an IL-18-dependent mechanism in driving the proliferative NK cell response. Responding NK cells have a less mature phenotype and a distinct chemokine-receptor imprint indicative of skin-homing. A corresponding NK cell subset can be localized to skin early during acute infection. These data provide evidence of an IL-18-driven NK cell proliferation and priming for skin-homing during an acute viral infection in humans. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000483017900007 |
WOS关键词 | NATURAL-KILLER-CELLS ; HUMAN CYTOMEGALOVIRUS-INFECTION ; CUTTING EDGE ; INHIBITORY RECEPTORS ; CHEMOKINE PRODUCTION ; INTERLEUKIN-18 ; EXPRESSION ; RESPONSES ; SUBSET ; IL-18 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203532 |
专题 | 资源环境科学 |
作者单位 | 1.Karolinska Univ Hosp, Karolinska Inst, Ctr Infect Med, Dept Med Huddinge, Stockholm, Sweden; 2.DUKE NUS Med Sch, Programme Emerging Infect Dis, Singapore, Singapore; 3.Tan Tock Seng Hosp, Communicable Dis Ctr, Inst Infect Dis & Epidemiol, Singapore, Singapore; 4.Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore; 5.Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore; 6.Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore; 7.Natl Univ Singapore, Life Sci Inst, Immunol Programme, Singapore, Singapore; 8.Natl Univ Singapore, Dept Microbiol & Immunol, Singapore, Singapore; 9.Univ Bristol, Sch Cellular & Mol Med, Bristol, Avon, England |
推荐引用方式 GB/T 7714 | Zimmer, Christine L.,Cornillet, Martin,Sola-Riera, Carles,et al. NK cells are activated and primed for skin-homing during acute dengue virus infection in humans[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Zimmer, Christine L..,Cornillet, Martin.,Sola-Riera, Carles.,Cheung, Ka-Wai.,Ivarsson, Martin A..,...&Bjorkstrom, Niklas K..(2019).NK cells are activated and primed for skin-homing during acute dengue virus infection in humans.NATURE COMMUNICATIONS,10. |
MLA | Zimmer, Christine L.,et al."NK cells are activated and primed for skin-homing during acute dengue virus infection in humans".NATURE COMMUNICATIONS 10(2019). |
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