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DOI | 10.1038/s41467-017-01321-w |
Caspase-11 signaling enhances graft-versus-host disease | |
Lu, Yanyan1; Meng, Ran1; Wang, Xiangyu1; Xu, Yajing2; Tang, Yiting3; Wu, Jianfeng4; Xue, Qianqian1; Yu, Songlin1; Duan, Mingwu1; Shan, Dongyong1; Wang, Qingde5; Wang, Haichao6; Billiar, Timothy R.5; Xiao, Xianzhong7,8; Chen, Fangping1; Lu, Ben1,7,8 | |
2019-09-06 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA |
英文摘要 | Acute graft-versus-host disease (GVHD) remains a major obstacle for the wider usage of allogeneic hematopoietic stem cell transplantation (allo-HSCT), which is an effective therapy for hematopoietic malignancy. Here we show that caspase-11, the cytosolic receptor for bacterial endotoxin (lipopolysaccharide: LPS), enhances GVHD severity. Allo-HSCT markedly increases the LPS-caspase-11 interaction, leading to the cleavage of gasdermin D (GSDMD). Caspase-11 and GSDMD mediate the release of interleukin-1 alpha (IL-1 alpha) in allo-HSCT. Deletion of Caspase-11 or Gsdmd, inhibition of LPS-caspase-11 interaction, or neutralizing IL-1 alpha uniformly reduces intestinal inflammation, tissue damage, donor T cell expansion and mortality in allo-HSCT. Importantly, Caspase-11 deficiency does not decrease the graft-versus-leukemia (GVL) activity, which is essential to prevent cancer relapse. These findings have major implications for allo-HSCT, as pharmacological interference with the caspase-11 signaling might reduce GVHD while preserving GVL activity. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000484598900011 |
WOS关键词 | NONCANONICAL-INFLAMMASOME ACTIVATION ; GASDERMIN D ; LPS ; TRANSPLANTATION ; PYROPTOSIS ; PROTECTS ; BACTERIA ; ANTIBODY ; DAMAGE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203516 |
专题 | 资源环境科学 |
作者单位 | 1.Cent S Univ, Xiangya Hosp 3, Dept Hematol & Crit Care Med, Changsha 410000, Hunan, Peoples R China; 2.Cent S Univ, Xiangya Hosp, Dept Hematol, Changsha 410008, Hunan, Peoples R China; 3.Cent S Univ, Dept Physiol, Sch Basic Med Sci, Changsha 410000, Hunan, Peoples R China; 4.Xiamen Univ, State Key Lab Cellular Stress Biol, Innovat Ctr Cell Signaling Network, Sch Life Sci, Xiamen 361005, Fujian, Peoples R China; 5.Northwell Hlth, Feinstein Inst Med Res, 350 Community Dr, Manhasset, NY 11030 USA; 6.Univ Pittsburgh, Med Ctr, Dept Surg, Pittsburgh, PA 15213 USA; 7.Cent S Univ, Key Lab Sepsis Translat Med Hunan, Changsha 410000, Hunan, Peoples R China; 8.Cent S Univ, Sch Basic Med Sci, Dept Pathophysiol, Changsha 410000, Hunan, Peoples R China |
推荐引用方式 GB/T 7714 | Lu, Yanyan,Meng, Ran,Wang, Xiangyu,et al. Caspase-11 signaling enhances graft-versus-host disease[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Lu, Yanyan.,Meng, Ran.,Wang, Xiangyu.,Xu, Yajing.,Tang, Yiting.,...&Lu, Ben.(2019).Caspase-11 signaling enhances graft-versus-host disease.NATURE COMMUNICATIONS,10. |
MLA | Lu, Yanyan,et al."Caspase-11 signaling enhances graft-versus-host disease".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
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