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DOI | 10.1038/s41467-017-00703-4 |
Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A | |
Im, Eun-Ju1; Lee, Chan-Hyeong1; Moon, Pyong-Gon1; Rangaswamy, Gunassekaran Gowri2; Lee, Byungheon2; Lee, Jae Man2; Lee, Jae-Chul3; Jee, Jun-Goo4; Bae, Jong-Sup4; Kwon, Taeg-Kyu5,6; Kang, Keon-Wook7,8; Jeong, Myeong-Seon9,10; Lee, Joo-Eun10; Jung, Hyun-Suk10; Ro, Hyun-Joo11; Jun, Sangmi11; Kang, Wonku12; Seo, Seung-Yong13,14; Cho, Young-Eun15; Song, Byoung-Joon15; Baek, Moon-Chang1 | |
2019-03-27 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | South Korea; USA |
英文摘要 | Inhibitors of the secretion of cancer exosomes, which promote cancer progression and metastasis, may not only accelerate exosome biology research but also offer therapeutic benefits for cancer patients. Here we identify sulfisoxazole (SFX) as an inhibitor of small extracellular vesicles (sEV) secretion from breast cancer cells through interference with endothelin receptor A (ETA). SFX, an FDA-approved oral antibiotic, showed significant anti-tumor and anti-metastatic effects in mouse models of breast cancer xenografts, the reduced expression of proteins involved in biogenesis and secretion of sEV, and triggered co-localization of multivesicular endosomes with lysosomes for degradation. We demonstrate the important role of ETA, as target of SFX, by gain- and loss-of-function studies of the ETA protein, through a direct binding assay, and pharmacological and genetic approaches. These findings may provide a foundation for sEV-targeted cancer therapies and the mechanistic studies on sEV biology. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000462458900002 |
WOS关键词 | CANCER EXOSOMES ; BIOGENESIS ; RELEASE ; IDENTIFICATION ; ANTAGONISTS ; INSIGHTS ; CELLS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203466 |
专题 | 资源环境科学 |
作者单位 | 1.Kyungpook Natl Univ, ECRC, Sch Med, Dept Mol Med,CMRI, Daegu 41944, South Korea; 2.Kyungpook Natl Univ, Dept Biochem & Cell Biol, Sch Med, Daegu 41944, South Korea; 3.Kyungpook Natl Univ, Dept Microbiol, Sch Med, Daegu 41944, South Korea; 4.Kyungpook Natl Univ, Res Inst Pharmaceut Res, Coll Pharm, Daegu 41566, South Korea; 5.Keimyung Univ, Dept Immunol, Daegu 42601, South Korea; 6.Keimyung Univ, Sch Med, Daegu 42601, South Korea; 7.Seoul Natl Univ, Coll Pharm, Seoul 08826, South Korea; 8.Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul 08826, South Korea; 9.Korean Basic Sci Inst, Chuncheon Ctr, Gangwon Do 24341, South Korea; 10.Kangwon Natl Univ, Coll Nat Sci, Dept Biochem, Gangwon Do 24341, South Korea; 11.Korea Basic Sci Inst, Drug & Dis Target Grp, Cheongju 28119, South Korea; 12.Chung Ang Univ, Coll Pharm, Seoul 06974, South Korea; 13.Gachon Univ, Coll Pharm, Incheon 21936, South Korea; 14.Gachon Univ, Gachon Inst Pharmaceut Sci, Incheon 21936, South Korea; 15.NIAAA, Sect Mol Pharmacol & Toxicol, Lab Membrane Biochem & Biophys, Bethesda, MD 20892 USA |
推荐引用方式 GB/T 7714 | Im, Eun-Ju,Lee, Chan-Hyeong,Moon, Pyong-Gon,et al. Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Im, Eun-Ju.,Lee, Chan-Hyeong.,Moon, Pyong-Gon.,Rangaswamy, Gunassekaran Gowri.,Lee, Byungheon.,...&Baek, Moon-Chang.(2019).Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A.NATURE COMMUNICATIONS,10. |
MLA | Im, Eun-Ju,et al."Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A".NATURE COMMUNICATIONS 10(2019). |
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