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DOI | 10.1038/ncomms15798 |
A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription | |
Platanitis, Ekaterini1; Demiroz, Duygu1; Schneller, Anja1; Fischer, Katrin1; Capelle, Christophe1; Hartl, Markus1; Gossenreiter, Thomas1; Mueller, Mathias2; Novatchkova, Maria3,4; Decker, Thomas1 | |
2019-07-02 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Austria |
英文摘要 | Cells maintain the balance between homeostasis and inflammation by adapting and integrating the activity of intracellular signaling cascades, including the JAK-STAT pathway. Our understanding of how a tailored switch from homeostasis to a strong receptor-dependent response is coordinated remains limited. Here, we use an integrated transcriptomic and proteomic approach to analyze transcription-factor binding, gene expression and in vivo proximity-dependent labelling of proteins in living cells under homeostatic and interferon (IFN)-induced conditions. We show that interferons (IFN) switch murine macrophages from resting-state to induced gene expression by alternating subunits of transcription factor ISGF3. Whereas preformed STAT2-IRF9 complexes control basal expression of IFN-induced genes (ISG), both type I IFN and IFN-gamma cause promoter binding of a complete ISGF3 complex containing STAT1, STAT2 and IRF9. In contrast to the dogmatic view of ISGF3 formation in the cytoplasm, our results suggest a model wherein the assembly of the ISGF3 complex occurs on DNA. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000473425900003 |
WOS关键词 | HEMATOPOIETIC STEM-CELLS ; INDUCED NUCLEAR FACTORS ; COMPUTATIONAL PLATFORM ; PROMOTER ELEMENT ; STAT1 ; DNA ; RESPONSES ; PROTEIN ; EXPRESSION ; IMMUNITY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203349 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Vienna, MPL, A-1030 Vienna, Austria; 2.Univ Vet Med Vienna, Inst Anim Breeding & Genet, A-1210 Vienna, Austria; 3.Austrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria; 4.Vienna Bioctr VBC, Res Inst Mol Pathol IMP, A-1030 Vienna, Austria |
推荐引用方式 GB/T 7714 | Platanitis, Ekaterini,Demiroz, Duygu,Schneller, Anja,et al. A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Platanitis, Ekaterini.,Demiroz, Duygu.,Schneller, Anja.,Fischer, Katrin.,Capelle, Christophe.,...&Decker, Thomas.(2019).A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription.NATURE COMMUNICATIONS,10. |
MLA | Platanitis, Ekaterini,et al."A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription".NATURE COMMUNICATIONS 10(2019). |
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