Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/ncomms15595 |
RNA editing is abundant and correlates with task performance in a social bumblebee | |
Porath, Hagit T.1; Hazan, Esther2; Shpigler, Hagai2; Cohen, Mira2; Band, Mark3,4; Ben-Shahar, Yehuda5; Levanon, Erez Y.1; Eisenberg, Eli6,7; Bloch, Guy2 | |
2019-04-08 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Israel; USA |
英文摘要 | Colonies of the bumblebee Bombus terrestris are characterized by wide phenotypic variability among genetically similar full-sister workers, suggesting a major role for epigenetic processes. Here, we report a high level of ADAR-mediated RNA editing in the bumblebee, despite the lack of an ADAR1-homolog. We identify 1.15 million unique genomic sites, and 164 recoding sites residing in 100 protein coding genes, including ion channels, transporters, and receptors predicted to affect brain function and behavior. Some edited sites are similarly edited in other insects, cephalopods and even mammals. The global editing level of protein coding and non-coding transcripts weakly correlates with task performance (brood care vs. foraging), but not affected by dominance rank or juvenile hormone known to influence physiology and behavior. Taken together, our findings show that brain editing levels are high in naturally behaving bees, and may be regulated by relatively short-term effects associated with brood care or foraging activities. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000463695400020 |
WOS关键词 | GENOME-WIDE ANALYSIS ; MESSENGER-RNA ; ADENOSINE DEAMINASES ; JUVENILE-HORMONE ; APIS-MELLIFERA ; DROSOPHILA ; ADAR1 ; CHANNELS ; BEHAVIOR ; ORGANIZATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203333 |
专题 | 资源环境科学 |
作者单位 | 1.Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-52900 Ramat Gan, Israel; 2.Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, Dept Ecol Evolut & Behav, IL-91904 Jerusalem, Israel; 3.Univ Illinois, Roy J Carver Biotechnol Ctr, Urbana, IL 61801 USA; 4.Univ Haifa, Inst Evolut, IL-3498838 Haifa, Israel; 5.Washington Univ, Dept Biol, Campus Box 1137, St Louis, MO 63130 USA; 6.Tel Aviv Univ, Raymond & Beverly Sackler Sch Phys & Astron, IL-6997801 Tel Aviv, Israel; 7.Tel Aviv Univ, Sagol Sch Neurosci, IL-6997801 Tel Aviv, Israel |
推荐引用方式 GB/T 7714 | Porath, Hagit T.,Hazan, Esther,Shpigler, Hagai,et al. RNA editing is abundant and correlates with task performance in a social bumblebee[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Porath, Hagit T..,Hazan, Esther.,Shpigler, Hagai.,Cohen, Mira.,Band, Mark.,...&Bloch, Guy.(2019).RNA editing is abundant and correlates with task performance in a social bumblebee.NATURE COMMUNICATIONS,10. |
MLA | Porath, Hagit T.,et al."RNA editing is abundant and correlates with task performance in a social bumblebee".NATURE COMMUNICATIONS 10(2019). |
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