Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/ncomms15702 |
Acto-myosin force organization modulates centriole separation and PLK4 recruitment to ensure centriole fidelity | |
Vitiello, Elisa1; Moreau, Philippe1; Nunes, Vanessa2,3; Mettouchi, Amel4; Maiato, Helder2,3,5; Ferreira, Jorge G.2,3,5; Wang, Irene1; Balland, Martial1 | |
2019-01-03 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | France; Portugal |
英文摘要 | The presence of aberrant number of centrioles is a recognized cause of aneuploidy and hallmark of cancer. Hence, centriole duplication needs to be tightly regulated. It has been proposed that centriole separation limits centrosome duplication. The mechanism driving centriole separation is poorly understood and little is known on how this is linked to centriole duplication. Here, we propose that actin-generated forces regulate centriole separation. By imposing geometric constraints via micropatterns, we were able to prove that precise actomyosin force arrangements control direction, distance and time of centriole separation. Accordingly, inhibition of acto-myosin contractility impairs centriole separation. Alongside, we observed that organization of acto-myosin force modulates specifically the length of S-G2 phases of the cell cycle, PLK4 recruitment at the centrosome and centriole fidelity. These discoveries led us to suggest that acto-myosin forces might act in fundamental mechanisms of aneuploidy prevention. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000454757900003 |
WOS关键词 | CENTROSOME AMPLIFICATION ; CHROMOSOMAL INSTABILITY ; BLEBBISTATIN INHIBITION ; ARP2/3 COMPLEX ; POLO KINASE ; DUPLICATION ; SATELLITE ; CYTOKINESIS ; PERICENTRIN ; BIOGENESIS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203327 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Joseph Fourier Grenoble 1, Domaine Univ, Lab Interdisciplinaire Phys, Bat E45 140,Rue Phys,BP 87, F-38402 St Martin Dheres 9, France; 2.Univ Porto, Inst Biol Mol & Celular, Chromosome Instabil & Dynam Lab, Rua Alfredo Allen 208, P-4200135 Porto, Portugal; 3.Univ Porto, i3S, Rua Alfredo Allen 208, P-4200135 Porto, Portugal; 4.Univ Paris 05, Unite Toxines Bacteriennes, Dept Microbiol, Inst Pasteur, 25-28 Rue Dr Roux, F-75015 Paris, France; 5.Univ Porto, Fac Med, Dept Biomed, Cell Div Grp,Expt Biol Unit, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal |
推荐引用方式 GB/T 7714 | Vitiello, Elisa,Moreau, Philippe,Nunes, Vanessa,et al. Acto-myosin force organization modulates centriole separation and PLK4 recruitment to ensure centriole fidelity[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Vitiello, Elisa.,Moreau, Philippe.,Nunes, Vanessa.,Mettouchi, Amel.,Maiato, Helder.,...&Balland, Martial.(2019).Acto-myosin force organization modulates centriole separation and PLK4 recruitment to ensure centriole fidelity.NATURE COMMUNICATIONS,10. |
MLA | Vitiello, Elisa,et al."Acto-myosin force organization modulates centriole separation and PLK4 recruitment to ensure centriole fidelity".NATURE COMMUNICATIONS 10(2019). |
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