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DOI | 10.1038/ncomms14389 |
Bacteria evoke alarm behaviour in zebrafish | |
Chia, Joanne Shu Ming1; Wall, Elena S.2; Wee, Caroline Lei3; Rowland, Thomas A. J.1,5; Cheng, Ruey-Kuang1; Cheow, Kathleen1; Guillemin, Karen2,4; Jesuthasan, Suresh1,3 | |
2019-08-23 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Singapore; USA; Canada; England |
英文摘要 | When injured, fish release an alarm substance (Schreckstoff) that elicits fear in members of their shoal. Although Schreckstoff has been proposed to be produced by club cells in the skin, several observations indicate that these giant cells function primarily in immunity. Previous data indicate that the alarm substance can be isolated from mucus. Here we show that mucus, as well as bacteria, are transported from the external surface into club cells, by cytoplasmic transfer or invasion of cells, including neutrophils. The presence of bacteria inside club cells raises the possibility that the alarm substance may contain a bacterial component. Indeed, lysate from a zebrafish Staphylococcus isolate is sufficient to elicit alarm behaviour, acting in concert with a substance from fish. These results suggest that Schreckstoff, which allows one individual to unwittingly change the emotional state of the surrounding population, derives from two kingdoms and is associated with processes that protect the host from bacteria. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000482398900033 |
WOS关键词 | EPIDERMAL CLUB CELLS ; CARP CYPRINUS-CARPIO ; SUBSTANCE CELLS ; CELLULAR-RESPONSES ; FRIGHT REACTION ; SKIN ; MUCUS ; RECEPTOR ; SIGNALS ; ENTOSIS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203224 |
专题 | 资源环境科学 |
作者单位 | 1.Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore; 2.Univ Oregon, Inst Mol Biol, Eugene, OR 97403 USA; 3.Inst Mol & Cell Biol, Singapore, Singapore; 4.Canadian Inst Adv Res, Humans & Microbiome Program, Toronto, ON M5G 1Z8, Canada; 5.Univ Oxford, St Edmund Hall, Oxford, England |
推荐引用方式 GB/T 7714 | Chia, Joanne Shu Ming,Wall, Elena S.,Wee, Caroline Lei,et al. Bacteria evoke alarm behaviour in zebrafish[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Chia, Joanne Shu Ming.,Wall, Elena S..,Wee, Caroline Lei.,Rowland, Thomas A. J..,Cheng, Ruey-Kuang.,...&Jesuthasan, Suresh.(2019).Bacteria evoke alarm behaviour in zebrafish.NATURE COMMUNICATIONS,10. |
MLA | Chia, Joanne Shu Ming,et al."Bacteria evoke alarm behaviour in zebrafish".NATURE COMMUNICATIONS 10(2019). |
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