Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/ncomms14134 |
Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor | |
Adhikary, Santanu1,2; Chakravarti, Deepavali3,4; Terranova, Christopher3; Sengupta, Isha1; Maitituoheti, Mayinuer3; Dasgupta, Anirban2; Srivastava, Dushyant Kumar2; Ma, Junsheng5; Raman, Ayush T.3; Tarco, Emily6,7; Sahin, Aysegul A.8; Bassett, Roland5; Yang, Fei6,7; Tapia, Coya8; Roy, Siddhartha2; Rai, Kunal3; Das, Chandrima1 | |
2019-03-28 | |
发表期刊 | NATURE COMMUNICATIONS
![]() |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | India; USA |
英文摘要 | The roles of Plant Homeodomain (PHD) fingers in catalysis of histone modifications are unknown. We demonstrated that the PHD finger of Ubiquitin Protein Ligase E3 Component N-Recognin7 (UBR7) harbors E3 ubiquitin ligase activity toward monoubiquitination of histone H2B at lysine120 (H2BK120Ub). Purified PHD finger or full-length UBR7 monoubiquitinated H2BK120 in vitro, and loss of UBR7 drastically reduced H2BK120Ub genome-wide binding sites in MCF10A cells. Low UBR7 expression was correlated with occurrence of triple-negative breast cancer and metastatic tumors. Consistently, UBR7 knockdown enhanced the invasiveness, induced epithelial-to-mesenchymal transition and promoted metastasis. Conversely, ectopic expression of UBR7 restored these cellular phenotypes and reduced tumor growth. Mechanistically, UBR7 loss reduced H2BK120Ub levels on cell adhesion genes, including CDH4, and upregulated the Wnt/beta-Catenin signaling pathway. CDH4 overexpression could partially revert UBR7-dependent cellular phenotypes. Collectively, our results established UBR7 as a histone H2B monoubiquitin ligase that suppresses tumorigenesis and metastasis of triple-negative breast cancer. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000462583000001 |
WOS关键词 | UBIQUITIN LIGASE ; HISTONE UBIQUITYLATION ; READ ALIGNMENT ; PHD FINGER ; CANCER ; RECOGNITION ; COMPLEX ; GENES ; METASTASIS ; CADHERINS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203219 |
专题 | 资源环境科学 |
作者单位 | 1.Saha Inst Nucl Phys, Biophys & Struct Genom Div, 1 AF Bidhan Nagar, Kolkata 700064, India; 2.CSIR Indian Inst Chem Biol, Struct Biol & Bioinformat Div, 4 Raja SC Mullick Rd, Kolkata 700032, India; 3.Univ Texas MD Anderson Canc Ctr, Dept Genom Med, Houston, TX 77030 USA; 4.Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA; 5.Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA; 6.Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, Houston, TX 77030 USA; 7.Univ Texas MD Anderson Canc Ctr, Dept Invest Canc Therapeut, Houston, TX 77030 USA; 8.Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA |
推荐引用方式 GB/T 7714 | Adhikary, Santanu,Chakravarti, Deepavali,Terranova, Christopher,et al. Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Adhikary, Santanu.,Chakravarti, Deepavali.,Terranova, Christopher.,Sengupta, Isha.,Maitituoheti, Mayinuer.,...&Das, Chandrima.(2019).Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor.NATURE COMMUNICATIONS,10. |
MLA | Adhikary, Santanu,et al."Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论