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DOI | 10.1038/ncomms14314 |
Ventral tegmental area astrocytes orchestrate avoidance and approach behavior | |
Gomez, J. A.1; Perkins, J. M.1; Beaudoin, G. M.1,2; Cook, N. B.1; Quraishi, S. A.1; Szoeke, E. A.1; Thangamani, K.1; Tschumi, C. W.3; Wanat, M. J.1; Maroof, A. M.1; Beckstead, M. J.3; Rosenberg, P. A.4,5; Paladini, C. A.1 | |
2019-03-29 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The ventral tegmental area (VTA) is a heterogeneous midbrain structure, containing neurons and astrocytes, that coordinates behaviors by integrating activity from numerous afferents. Within neuron-astrocyte networks, astrocytes control signals from distinct afferents in a circuit-specific manner, but whether this capacity scales up to drive motivated behavior has been undetermined. Using genetic and optical dissection strategies we report that VTA astrocytes tune glutamatergic signaling selectively on local inhibitory neurons to drive a functional circuit for learned avoidance. In this circuit, astrocytes facilitate excitation of VTA GABA neurons to increase inhibition of dopamine neurons, eliciting real-time and learned avoidance behavior that is sufficient to impede expression of preference for reward. Loss of one glutamate transporter (GLT-1) from VTA astrocytes selectively blocks these avoidance behaviors and spares preference for reward. Thus, VTA astrocytes selectively regulate excitation of local GABA neurons to drive a distinct avoidance circuit that opposes approach behavior. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000462722700002 |
WOS关键词 | GLUTAMATE TRANSPORTER GLT-1 ; DOPAMINE NEURONS ; CONDITIONAL DELETION ; GABA NEURONS ; GLIAL-CELLS ; RECEPTORS ; CURRENTS ; DYNAMICS ; INFORMATION ; ACTIVATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203211 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Texas San Antonio, Neurosci Inst, Dept Biol, San Antonio, TX 78249 USA; 2.Trinity Univ, Dept Biol, San Antonio, TX 78212 USA; 3.Oklahoma Med Res Fdn, Aging & Metab Res Program, 825 NE 13th St, Oklahoma City, OK 73104 USA; 4.Boston Childrens Hosp, Dept Neurol, Boston, MA 02115 USA; 5.Boston Childrens Hosp, FM Kirby Neurobiol Ctr, Boston, MA 02115 USA |
推荐引用方式 GB/T 7714 | Gomez, J. A.,Perkins, J. M.,Beaudoin, G. M.,et al. Ventral tegmental area astrocytes orchestrate avoidance and approach behavior[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Gomez, J. A..,Perkins, J. M..,Beaudoin, G. M..,Cook, N. B..,Quraishi, S. A..,...&Paladini, C. A..(2019).Ventral tegmental area astrocytes orchestrate avoidance and approach behavior.NATURE COMMUNICATIONS,10. |
MLA | Gomez, J. A.,et al."Ventral tegmental area astrocytes orchestrate avoidance and approach behavior".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
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