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DOI | 10.1038/ncomms14375 |
Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response | |
Li, Shang-Ze1,2; Shu, Qi-Peng1; Song, Yang1; Zhang, Hui-Hui3; Liu, Yi1; Jin, Bing-Xue1; Liuyu, Tian-Zi4; Li, Chao1; Huang, Xi-Chen1; Du, Run-Lei1; Song, Wei5; Zhong, Bo4; Zhang, Xiao-Dong1,2 | |
2019-07-19 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | MAVS is essential for antiviral immunity, but the molecular mechanisms responsible for its tight regulation remain poorly understood. Here, we show that NLK inhibits the antiviral immune response during viral infection by targeting MAVS for degradation. NLK depletion promotes virus-induced antiviral cytokine production and decreases viral replication, which is potently rescued by the reintroduction of NLK. Moreover, the depletion of NLK promotes antiviral effects and increases the survival times of mice after infection with VSV. NLK interacts with and phosphorylates MAVS at multiple sites on mitochondria or peroxisomes, thereby inducing the degradation of MAVS and subsequent inactivation of IRF3. Most importantly, a peptide derived from MAVS promotes viral-induced IFN-beta production and antagonizes viral replication in vitro and in vivo. These findings provide direct insights into the molecular mechanisms by which phosphorylation of MAVS regulates its degradation and influences its activation and identify an important peptide target for propagating antiviral responses. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000476471300041 |
WOS关键词 | DOUBLE-STRANDED-RNA ; NF-KAPPA-B ; RIG-I ; PATHOGEN RECOGNITION ; ADAPTER PROTEIN ; MAVS ; SUPPRESSES ; ACTIVATION ; INDUCTION ; PATHWAY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203208 |
专题 | 资源环境科学 |
作者单位 | 1.Wuhan Univ, Coll Life Sci, Hubei Key Lab Cell Homeostasis, Wuhan 430072, Hubei, Peoples R China; 2.Wuhan Univ, Med Sci Res Ctr, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China; 3.Hunan Normal Univ, Coll Med, Changsha 410013, Hunan, Peoples R China; 4.Wuhan Univ, Coll Life Sci, Wuhan 430072, Hubei, Peoples R China; 5.Chinese Acad Med Sci, Peking Union Med Coll, Inst Basic Med Sci, Dept Biochem & Mol Biol,State Key Lab Med Mol Bio, Beijing 100005, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Shang-Ze,Shu, Qi-Peng,Song, Yang,et al. Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Li, Shang-Ze.,Shu, Qi-Peng.,Song, Yang.,Zhang, Hui-Hui.,Liu, Yi.,...&Zhang, Xiao-Dong.(2019).Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response.NATURE COMMUNICATIONS,10. |
MLA | Li, Shang-Ze,et al."Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response".NATURE COMMUNICATIONS 10(2019). |
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