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DOI | 10.1038/ncomms14368 |
Cerebellar disruption impairs working memory during evidence accumulation | |
Deverett, Ben1,2; Kislin, Mikhail1; Tank, David W.1; Wang, Samuel S-H1 | |
2019-07-16 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | To select actions based on sensory evidence, animals must create and manipulate representations of stimulus information in memory. Here we report that during accumulation of somatosensory evidence, optogenetic manipulation of cerebellar Purkinje cells reduces the accuracy of subsequent memory-guided decisions and causes mice to downweight prior information. Behavioral deficits are consistent with the addition of noise and leak to the evidence accumulation process. We conclude that the cerebellum can influence the accurate maintenance of working memory. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000475566800009 |
WOS关键词 | DECISION-MAKING |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203196 |
专题 | 资源环境科学 |
作者单位 | 1.Princeton Univ, Neurosci Inst, Princeton, NJ 08544 USA; 2.Rutgers Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA |
推荐引用方式 GB/T 7714 | Deverett, Ben,Kislin, Mikhail,Tank, David W.,et al. Cerebellar disruption impairs working memory during evidence accumulation[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Deverett, Ben,Kislin, Mikhail,Tank, David W.,&Wang, Samuel S-H.(2019).Cerebellar disruption impairs working memory during evidence accumulation.NATURE COMMUNICATIONS,10. |
MLA | Deverett, Ben,et al."Cerebellar disruption impairs working memory during evidence accumulation".NATURE COMMUNICATIONS 10(2019). |
条目包含的文件 | 条目无相关文件。 |
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