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DOI | 10.1126/science.aay4199 |
Higher-fitness yeast genotypes are less robust to deleterious mutations | |
Johnson, Milo S.1,2,3; Martsul, Alena4; Kryazhimskiy, Sergey4; Desai, Michael M.1,2,3,5 | |
2019-10-25 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6464页码:490-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Natural selection drives populations toward higher fitness, but second-order selection for adaptability and mutational robustness can also influence evolution. In many microbial systems, diminishing-returns epistasis contributes to a tendency for more-fit genotypes to be less adaptable, but no analogous patterns for robustness are known. To understand how robustness varies across genotypes, we measure the fitness effects of hundreds of individual insertion mutations in a panel of yeast strains. We find that more-fit strains are less robust: They have distributions of fitness effects with lower mean and higher variance. These differences arise because many mutations have more strongly deleterious effects in faster-growing strains. This negative correlation between fitness and robustness implies that second-order selection for robustness will tend to conflict with first-order selection for fitness. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000493177900047 |
WOS关键词 | METABOLIC-CONTROL-THEORY ; BENEFICIAL MUTATIONS ; EPISTASIS ; EVOLUTION ; SEQUENCE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202633 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA; 2.Harvard Univ, Quantitat Biol Initiat, Cambridge, MA 02138 USA; 3.Harvard Univ, NSF Simons Ctr Math & Stat Anal Biol, Cambridge, MA 02138 USA; 4.Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA; 5.Harvard Univ, Dept Phys, Cambridge, MA 02138 USA |
推荐引用方式 GB/T 7714 | Johnson, Milo S.,Martsul, Alena,Kryazhimskiy, Sergey,et al. Higher-fitness yeast genotypes are less robust to deleterious mutations[J]. SCIENCE,2019,366(6464):490-+. |
APA | Johnson, Milo S.,Martsul, Alena,Kryazhimskiy, Sergey,&Desai, Michael M..(2019).Higher-fitness yeast genotypes are less robust to deleterious mutations.SCIENCE,366(6464),490-+. |
MLA | Johnson, Milo S.,et al."Higher-fitness yeast genotypes are less robust to deleterious mutations".SCIENCE 366.6464(2019):490-+. |
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