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DOI | 10.1126/science.aav9199 |
Persistence of neuronal representations through time and damage in the hippocampus | |
Gonzalez, Walter G.; Zhang, Hanwen; Harutyunyan, Anna; Lois, Carlos | |
2019-08-23 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6455页码:821-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | How do neurons encode long-term memories? Bilateral imaging of neuronal activity in the mouse hippocampus reveals that, from one day to the next, similar to 40% of neurons change their responsiveness to cues, but thereafter only 1% of cells change per day. Despite these changes. neuronal responses are resilient to a lack of exposure to a previously completed task or to hippocampus lesions. Unlike individual neurons, the responses of which change after a few days, groups of neurons with inter- and intrahemispheric synchronous activity show stable responses for several weeks. The likelihood that a neuron maintains its responsiveness across days is proportional to the number of neurons with which its activity is synchronous. Information stored in individual neurons is relatively labile, but it can be reliably stored in networks of synchronously active neurons. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000482464000054 |
WOS关键词 | CELL ASSEMBLIES ; MEMORY ; DYNAMICS ; EXPERIENCE ; MOUSE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202142 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA |
推荐引用方式 GB/T 7714 | Gonzalez, Walter G.,Zhang, Hanwen,Harutyunyan, Anna,et al. Persistence of neuronal representations through time and damage in the hippocampus[J]. SCIENCE,2019,365(6455):821-+. |
APA | Gonzalez, Walter G.,Zhang, Hanwen,Harutyunyan, Anna,&Lois, Carlos.(2019).Persistence of neuronal representations through time and damage in the hippocampus.SCIENCE,365(6455),821-+. |
MLA | Gonzalez, Walter G.,et al."Persistence of neuronal representations through time and damage in the hippocampus".SCIENCE 365.6455(2019):821-+. |
条目包含的文件 | 条目无相关文件。 |
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