Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaw5202 |
Cortical layer-specific critical dynamics triggering perception | |
Marshel, James H.1; Kim, Yoon Seok2; Machado, Timothy A.1,2; Quirin, Sean1; Benson, Brandon3; Kadmon, Jonathan3; Raja, Cephra2; Chibukhchyan, Adelaida2; Ramakrishnan, Charu2; Inoue, Masatoshi2; Shane, Janelle C.4; McKnight, Douglas J.4; Yoshizawa, Susumu5; Kato, Hideaki E.6; Ganguli, Surya3; Deisseroth, Karl1,2,7,8 | |
2019-08-09 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6453页码:558-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Japan |
英文摘要 | Perceptual experiences may arise from neuronal activity patterns in mammalian neocortex. We probed mouse neocortex during visual discrimination using a red-shifted channelrhodopsin (ChRmine, discovered through structure-guided genome mining) alongside multiplexed multiphoton-holography (MultiSLM), achieving control of individually specified neurons spanning large cortical volumes with millisecond precision. Stimulating a critical number of stimulus-orientation-selective neurons drove widespread recruitment of functionally related neurons, a process enhanced by (but not requiring) orientation-discrimination task learning. Optogenetic targeting of orientation-selective ensembles elicited correct behavioral discrimination. Cortical layer-specific dynamics were apparent, as emergent neuronal activity asymmetrically propagated from layer 2/3 to layer 5, and smaller layer 5 ensembles were as effective as larger layer 2/3 ensembles in eliciting orientation discrimination behavior. Population dynamics emerging after optogenetic stimulation both correctly predicted behavior and resembled natural internal representations of visual stimuli at cellular resolution over volumes of cortex. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000483195200032 |
WOS关键词 | SPATIAL LIGHT-MODULATOR ; FUNCTIONAL SPECIALIZATION ; BALANCED AMPLIFICATION ; CIRCUIT ; NEURONS ; CONNECTIVITY ; EXCITATION ; NETWORK ; ILLUMINATION ; ORGANIZATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202047 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Stanford Univ, CNC Dept, Stanford, CA 94305 USA; 2.Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA; 3.Stanford Univ, Dept Appl Phys, Stanford, CA 94305 USA; 4.Boulder Nonlinear Syst, Lafayette, CO 80026 USA; 5.Univ Tokyo, Grad Sch Frontier Sci, Dept Nat Environm Studies, Kashiwa, Chiba 2778564, Japan; 6.Stanford Univ, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA; 7.Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA; 8.Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Marshel, James H.,Kim, Yoon Seok,Machado, Timothy A.,et al. Cortical layer-specific critical dynamics triggering perception[J]. SCIENCE,2019,365(6453):558-+. |
APA | Marshel, James H..,Kim, Yoon Seok.,Machado, Timothy A..,Quirin, Sean.,Benson, Brandon.,...&Deisseroth, Karl.(2019).Cortical layer-specific critical dynamics triggering perception.SCIENCE,365(6453),558-+. |
MLA | Marshel, James H.,et al."Cortical layer-specific critical dynamics triggering perception".SCIENCE 365.6453(2019):558-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论