Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aay0198 |
A vicious cycle of beta amyloid-dependent neuronal hyperactivation | |
Zott, Benedikt1,2; Simon, Manuel M.1,2; Hong, Wei3,4; Unger, Felix1,2; Chen-Engerer, Hsing-Jung1,2; Frosch, Matthew P.5; Sakmann, Bert1; Walsh, Dominic M.3,4,6; Konnerth, Arthur1,2 | |
2019-08-09 | |
发表期刊 | SCIENCE
![]() |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6453页码:559-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; USA |
英文摘要 | beta-amyloid (A beta)-dependent neuronal hyperactivity is believed to contribute to the circuit dysfunction that characterizes the early stages of Alzheimer's disease (AD). Although experimental evidence in support of this hypothesis continues to accrue, the underlying pathological mechanisms are not well understood. In this experiment, we used mouse models of A beta-amyloidosis to show that hyperactivation is initiated by the suppression of glutamate reuptake. Hyperactivity occurred in neurons with preexisting baseline activity, whereas inactive neurons were generally resistant to A beta-mediated hyperactivation. A beta-containing AD brain extracts and purified A beta dimers were able to sustain this vicious cycle. Our findings suggest a cellular mechanism of A beta-dependent neuronal dysfunction that can be active before plaque formation. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000483195200033 |
WOS关键词 | GLIAL GLUTAMATE TRANSPORTER ; LONG-TERM POTENTIATION ; ALZHEIMERS-DISEASE ; MOUSE MODEL ; SYNAPSE LOSS ; OLIGOMERS ; DIMERS ; ACTIVATION ; HYPOTHESIS ; DEPRESSION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202037 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Tech Univ Munich, Inst Neurosci, D-80802 Munich, Germany; 2.Tech Univ Munich, Munich Cluster Syst Neurol, D-80802 Munich, Germany; 3.Brigham & Womens Hosp, Ann Romney Ctr Neurol Dis, Lab Neurodegenerat Res, 75 Francis St, Boston, MA 02115 USA; 4.Harvard Med Sch, Boston, MA 02115 USA; 5.Massachusetts Gen Hosp, CS Kubik Lab Neuropathol, Boston, MA 02114 USA; 6.Biogen, Alzheimers Dis & Dementia Res Unit, Boston, MA USA |
推荐引用方式 GB/T 7714 | Zott, Benedikt,Simon, Manuel M.,Hong, Wei,et al. A vicious cycle of beta amyloid-dependent neuronal hyperactivation[J]. SCIENCE,2019,365(6453):559-+. |
APA | Zott, Benedikt.,Simon, Manuel M..,Hong, Wei.,Unger, Felix.,Chen-Engerer, Hsing-Jung.,...&Konnerth, Arthur.(2019).A vicious cycle of beta amyloid-dependent neuronal hyperactivation.SCIENCE,365(6453),559-+. |
MLA | Zott, Benedikt,et al."A vicious cycle of beta amyloid-dependent neuronal hyperactivation".SCIENCE 365.6453(2019):559-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论