Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaw7709 |
Hydraulic fracturing and active coarsening position the lumen of the mouse blastocyst | |
Dumortier, Julien G.1; Le Verge-Serandour, Mathieu2; Tortorelli, Anna Francesca1; Mielke, Annette2; de Plater, Ludmilla1; Turlier, Herve2; Maitre, Jean-Leon1 | |
2019-08-02 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6452页码:465-+ |
文章类型 | Article |
语种 | 英语 |
国家 | France |
英文摘要 | During mouse pre-implantation development, the formation of the blastocoel, a fluid-filled lumen, breaks the radial symmetry of the blastocyst. The factors that control the formation and positioning of this basolateral lumen remain obscure. We found that accumulation of pressurized fluid fractures cell-cell contacts into hundreds of micrometer-size lumens. These microlumens eventually discharge their volumes into a single dominant lumen, which we model as a process akin to Ostwald ripening, underlying the coarsening of foams. Using chimeric mutant embryos, we tuned the hydraulic fracturing of cell-cell contacts and steered the coarsening of microlumens, allowing us to successfully manipulate the final position of the lumen. We conclude that hydraulic fracturing of cell-cell contacts followed by contractility-directed coarsening of microlumens sets the first axis of symmetry of the mouse embryo. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000485768400040 |
WOS关键词 | E-CADHERIN ; CELL FATE ; POLARITY ; EMBRYOS ; AXIS ; ULTRASTRUCTURE ; MORPHOGENESIS ; CAVITATION ; MECHANICS ; TENSION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201995 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Sorbonne Univ, PSL Res Univ, Inst Curie, CNRS,INSERM,U934,UMR3215, Paris, France; 2.PSL Res Univ, CNRS, Ctr Interdisciplinary Res Biol, Coll France,INSERM,U1050,UMR7241, F-75005 Paris, France |
推荐引用方式 GB/T 7714 | Dumortier, Julien G.,Le Verge-Serandour, Mathieu,Tortorelli, Anna Francesca,et al. Hydraulic fracturing and active coarsening position the lumen of the mouse blastocyst[J]. SCIENCE,2019,365(6452):465-+. |
APA | Dumortier, Julien G..,Le Verge-Serandour, Mathieu.,Tortorelli, Anna Francesca.,Mielke, Annette.,de Plater, Ludmilla.,...&Maitre, Jean-Leon.(2019).Hydraulic fracturing and active coarsening position the lumen of the mouse blastocyst.SCIENCE,365(6452),465-+. |
MLA | Dumortier, Julien G.,et al."Hydraulic fracturing and active coarsening position the lumen of the mouse blastocyst".SCIENCE 365.6452(2019):465-+. |
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