Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aat9351 |
T cell-mediated regulation of the microbiota protects against obesity | |
Petersen, Charisse1; 39;Connell, Ryan M.2 | |
2019-07-26 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6451页码:340-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The microbiota influences obesity, yet organisms that protect from disease remain unknown. During studies interrogating host-microbiota interactions, we observed the development of age-associated metabolic syndrome (MetS). Expansion of Desulfovibrio and loss of Clostridia were key features associated with obesity in this model and are present in humans with MetS. T cell-dependent events were required to prevent disease, and replacement of Clostridia rescued obesity. Inappropriate immunoglobulin A targeting of Clostridia and increased Desulfovibrio antagonized the colonization of beneficial Clostridia. Transcriptional and metabolic analysis revealed enhanced lipid absorption in the obese host. Colonization of germ-free mice with Clostridia, but not Desulfovibrio, down-regulated genes that control lipid absorption and reduced adiposity. Thus, immune control of the microbiota maintains beneficial microbial populations that constrain lipid metabolism to prevent MetS. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000477703100031 |
WOS关键词 | GUT MICROBIOTA ; OVERWEIGHT ; ALIGNMENT ; BACTERIA ; IMMUNITY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201951 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Utah, Sch Med, Dept Pathol, Div Microbiol & Immunol, Salt Lake City, UT 84112 USA; 2.Univ Utah, Coll Hlth, Dept Nutr & Integrat Physiol, Salt Lake City, UT 84112 USA; 3.Univ Utah, Sch Med, Dept Biochem, Salt Lake City, UT 84112 USA |
推荐引用方式 GB/T 7714 | Petersen, Charisse,39;Connell, Ryan M.. T cell-mediated regulation of the microbiota protects against obesity[J]. SCIENCE,2019,365(6451):340-+. |
APA | Petersen, Charisse,&39;Connell, Ryan M..(2019).T cell-mediated regulation of the microbiota protects against obesity.SCIENCE,365(6451),340-+. |
MLA | Petersen, Charisse,et al."T cell-mediated regulation of the microbiota protects against obesity".SCIENCE 365.6451(2019):340-+. |
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