Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaw7733 |
IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise | |
Buchrieser, Julian1,2; Degrelle, Severine A.3,4,5; Couderc, Therese6,7; Nevers, Quentin1,2; Disson, Olivier6,7; Manet, Caroline8; Donahue, Daniel A.1,2; Porrot, Francoise1,2; Hillion, Kenzo-Hugo9; Perthame, Emeline9; Arroyo, Marlene V.1,2,10,11; Souquere, Sylvie12; Ruigrok, Katinka2,13; Dupressoir, Anne14,15; Heidmann, Thierry14,15; Montagutelli, Xavier8; Fournier, Thierry3,4; Lecuit, Marc6,7,16; Schwartz, Olivier1,2,17 | |
2019-07-12 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6449页码:176-+ |
文章类型 | Article |
语种 | 英语 |
国家 | France; USA |
英文摘要 | Elevated levels of type I interferon (IFN) during pregnancy are associated with intrauterine growth retardation, preterm birth, and fetal demise through mechanisms that are not well understood. A critical step of placental development is the fusion of trophoblast cells into a multinucleated syncytiotrophoblast (ST) layer. Fusion is mediated by syncytins, proteins deriving from ancestral endogenous retroviral envelopes. Using cultures of human trophoblasts or mouse cells, we show that IFN-induced transmembrane proteins (IFITMs), a family of restriction factors blocking the entry step of many viruses, impair ST formation and inhibit syncytin-mediated fusion. Moreover, the IFN inducer polyinosinic: polycytidylic acid promotes fetal resorption and placental abnormalities in wild-type but not in Ifitm-deleted mice. Thus, excessive levels of IFITMs may mediate the pregnancy complications observed during congenital infections and other IFN-induced pathologies. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000474905400045 |
WOS关键词 | SYNCYTIAL FUSION ; RESISTANCE ; FAMILY ; VIRUS ; GENES ; CELLS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201839 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Inst Pasteur, Dept Virol, Virus & Immun Unit, Paris, France; 2.CNRS, UMR3569, Paris, France; 3.Fac Pharm Paris, UMR S1139, INSERM, Paris, France; 4.Univ Paris 05, Sorbonne Paris Cite, Paris, France; 5.Inovarion, Paris, France; 6.Inst Pasteur, Biol Infect Unit, Paris, France; 7.INSERM, U1117, Paris, France; 8.Inst Pasteur, Dept Genomes & Genet, Mouse Genet Lab, Paris, France; 9.Inst Pasteur, Bioinformat & Biostat Hub, C3BI, USR 3756 IP,CNRS, Paris, France; 10.Columbia Univ, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, New York, NY 10032 USA; 11.Columbia Univ, Howard Hughes Med Inst, Dept Microbiol & Immunol, New York, NY 10032 USA; 12.Gustave Roussy, Plateforme Microscopie Elect Cellulaire, UMS AMMICA, Villejuif, France; 13.Inst Pasteur, Struct Virol Unit, Paris, France; 14.Gustave Roussy, Unite Physiol & Pathol Mol Retrovirus Endogenes &, CNRS, UMR 9196, Villejuif, France; 15.Univ Paris Sud, UMR 9196, Orsay, France; 16.Paris Descartes Univ, Necker Enfants Malades Univ Hosp, APHP, Inst Imagine,Dept Infect Dis & Trop Med, Paris, France; 17.Vaccine Res Inst, Creteil, France |
推荐引用方式 GB/T 7714 | Buchrieser, Julian,Degrelle, Severine A.,Couderc, Therese,et al. IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise[J]. SCIENCE,2019,365(6449):176-+. |
APA | Buchrieser, Julian.,Degrelle, Severine A..,Couderc, Therese.,Nevers, Quentin.,Disson, Olivier.,...&Schwartz, Olivier.(2019).IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise.SCIENCE,365(6449),176-+. |
MLA | Buchrieser, Julian,et al."IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise".SCIENCE 365.6449(2019):176-+. |
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