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DOI | 10.1126/science.aaw5030 |
Structured spike series specify gene expression patterns for olfactory circuit formation | |
Nakashima, Ai1; Ihara, Naoki1; Shigeta, Mayo2; Kiyonari, Hiroshi2,3; Ikegaya, Yuji1,4; Takeuchi, Haruki1,5 | |
2019-07-05 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6448页码:46-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Japan |
英文摘要 | Neural circuits emerge through the interplay of genetic programming and activity-dependent processes. During the development of the mouse olfactory map, axons segregate into distinct glomeruli in an olfactory receptor (OR)-dependent manner. ORs generate a combinatorial code of axon-sorting molecules whose expression is regulated by neural activity. However, it remains unclear how neural activity induces OR-specific expression patterns of axon-sorting molecules. We found that the temporal patterns of spontaneous neuronal spikes were not spatially organized but were correlated with the OR types. Receptor substitution experiments demonstrated that ORs determine spontaneous activity patterns. Moreover, optogenetically differentiated patterns of neuronal activity induced specific expression of the corresponding axon-sorting molecules and regulated axonal segregation. Thus, OR-dependent temporal patterns of spontaneous activity play instructive roles in generating the combinatorial code of axon-sorting molecules during olfactory map formation. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000474432700028 |
WOS关键词 | NEURAL MAP FORMATION ; ELECTRICAL-ACTIVITY ; ODORANT RECEPTORS ; SENSORY NEURONS ; MOLECULAR-BASIS ; CONVERGENCE ; INFORMATION ; REFINEMENT ; PROJECTION ; GLOMERULI |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201798 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Tokyo, Grad Sch Pharmaceut Sci, Chem Pharmacol Lab, Tokyo 1130033, Japan; 2.RIKEN Ctr Biosyst Dynam Res, Lab Anim Resource Dev, Chuo Ku, 2-2-3 Minatojima Minami Machi, Kobe, Hyogo 6500047, Japan; 3.RIKEN Ctr Biosyst Dynam Res, Genet Engn Lab, Chuo Ku, 2-2-3 Minatojima Minami Machi, Kobe, Hyogo 6500047, Japan; 4.Natl Inst Informat & Commun Technol, Ctr Informat & Neural Networks, Suita, Osaka 5650871, Japan; 5.Univ Tokyo, Grad Sch Pharmaceut Sci, Social Cooperat Program Evolut Chem Safety Assess, LECSAS, Tokyo 1130033, Japan |
推荐引用方式 GB/T 7714 | Nakashima, Ai,Ihara, Naoki,Shigeta, Mayo,et al. Structured spike series specify gene expression patterns for olfactory circuit formation[J]. SCIENCE,2019,365(6448):46-+. |
APA | Nakashima, Ai,Ihara, Naoki,Shigeta, Mayo,Kiyonari, Hiroshi,Ikegaya, Yuji,&Takeuchi, Haruki.(2019).Structured spike series specify gene expression patterns for olfactory circuit formation.SCIENCE,365(6448),46-+. |
MLA | Nakashima, Ai,et al."Structured spike series specify gene expression patterns for olfactory circuit formation".SCIENCE 365.6448(2019):46-+. |
条目包含的文件 | 条目无相关文件。 |
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