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DOI | 10.1126/science.aav7019 |
Direct arene C-H fluorination with F-18(-) via organic photoredox catalysis | |
Chen, Wei1,2; Huang, Zeng1,2; Tay, Nicholas E. S.3; Giglio, Benjamin1,2; Wang, Mengzhe1,2; Wang, Hui1,2; Wu, Zhanhong1,2; Nicewicz, David A.3; Li, Zibo1,2 | |
2019-06-21 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6446页码:1170-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Positron emission tomography (PET) plays key roles in drug discovery and development, as well as medical imaging. However, there is a dearth of efficient and simple radiolabeling methods for aromatic C-H bonds, which limits advancements in PET radiotracer development. Here, we disclose a mild method for the fluorine-18 (F-18)-fluorination of aromatic C-H bonds by an [F-18]F- salt via organic photoredox catalysis under blue light illumination. This strategy was applied to the synthesis of a wide range of F-18-labeled arenes and heteroaromatics, including pharmaceutical compounds. These products can serve as diagnostic agents or provide key information about the in vivo fate of the labeled substrates, as showcased in preliminary tracer studies in mice. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000472175100039 |
WOS关键词 | INHIBITORS ; PET ; SUBSTITUTION ; ARYL ; SITE ; F-18-FLUORINATION ; INFLAMMATION ; DERIVATIVES ; METABOLISM ; REAGENT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201706 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ North Carolina Chapel Hill, Biomed Res Imaging Ctr, Dept Radiol, Chapel Hill, NC 27514 USA; 2.Univ North Carolina Chapel Hill, UNC Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27514 USA; 3.Univ North Carolina Chapel Hill, Dept Chem, Chapel Hill, NC 27599 USA |
推荐引用方式 GB/T 7714 | Chen, Wei,Huang, Zeng,Tay, Nicholas E. S.,et al. Direct arene C-H fluorination with F-18(-) via organic photoredox catalysis[J]. SCIENCE,2019,364(6446):1170-+. |
APA | Chen, Wei.,Huang, Zeng.,Tay, Nicholas E. S..,Giglio, Benjamin.,Wang, Mengzhe.,...&Li, Zibo.(2019).Direct arene C-H fluorination with F-18(-) via organic photoredox catalysis.SCIENCE,364(6446),1170-+. |
MLA | Chen, Wei,et al."Direct arene C-H fluorination with F-18(-) via organic photoredox catalysis".SCIENCE 364.6446(2019):1170-+. |
条目包含的文件 | 条目无相关文件。 |
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