Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aau0236 |
Rapid molecular evolution of pain insensitivity in multiple African rodents | |
Eigenbrod, Ole1; Debus, Karlien Y.1; Reznick, Jane1; Bennett, Nigel C.2; Sanchez-Carranza, Oscar1; Omerbasic, Damir1; Hart, Daniel W.2; Barker, Alison J.1; Zhong, Wei1; Lutermann, Heike2; Katandukila, Jestina V.2,3; Mgode, Georgies4; Park, Thomas J.5; Lewin, Gary R.1,6 | |
2019-05-31 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6443页码:852-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; South Africa; Tanzania; USA |
英文摘要 | Noxious substances, called algogens, cause pain and are used as defensive weapons by plants and stinging insects. We identified four previously unknown instances of algogen-insensitivity by screening eight African rodent species related to the naked mole-rat with the painful substances capsaicin, acid (hydrogen chloride, pH 3.5), and allyl isothiocyanate (AITC). Using RNA sequencing, we traced the emergence of sequence variants in transduction channels, like transient receptor potential channel TRPA1 and voltage-gated sodium channel Na(v)1.7, that accompany algogen insensitivity. In addition, the AITC-insensitive highveld mole-rat exhibited overexpression of the leak channel NALCN (sodium leak channel, nonselective), ablating AITC detection by nociceptors. These molecular changes likely rendered highveld mole-rats immune to the stings of the Natal droptail ant. Our study reveals howevolution can be used as a discovery tool to find molecular mechanisms that shut down pain. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000469887900055 |
WOS关键词 | ION-CHANNEL ; FUNCTIONAL DIVERGENCE ; INFLAMMATORY PAIN ; READ ALIGNMENT ; TRPA1 ; FAMILY ; NERVE ; CONTRIBUTES ; MECHANISM ; REVEALS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201530 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Max Delbruck Ctr Mol Med, Mol Physiol Somat Sensat, Berlin, Germany; 2.Univ Pretoria, Mammal Res Inst, Dept Zool & Entomol, Pretoria, South Africa; 3.Univ Dar Es Salaam, Dept Zool & Wildlife Conservat, Coll Nat & Appl Sci, POB 35064, Dar Es Salaam, Tanzania; 4.Sokoine Univ Agr, Pest Management Ctr, Morogoro, Tanzania; 5.Univ Illinois, Dept Biol Sci, Lab Integrat Neurosci, Chicago, IL 60680 USA; 6.Charite Univ Med Berlin, NeuroCure Cluster Excellence, Berlin, Germany |
推荐引用方式 GB/T 7714 | Eigenbrod, Ole,Debus, Karlien Y.,Reznick, Jane,et al. Rapid molecular evolution of pain insensitivity in multiple African rodents[J]. SCIENCE,2019,364(6443):852-+. |
APA | Eigenbrod, Ole.,Debus, Karlien Y..,Reznick, Jane.,Bennett, Nigel C..,Sanchez-Carranza, Oscar.,...&Lewin, Gary R..(2019).Rapid molecular evolution of pain insensitivity in multiple African rodents.SCIENCE,364(6443),852-+. |
MLA | Eigenbrod, Ole,et al."Rapid molecular evolution of pain insensitivity in multiple African rodents".SCIENCE 364.6443(2019):852-+. |
条目包含的文件 | 条目无相关文件。 |
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