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DOI | 10.1126/science.aaw3053 |
Conformationally supple glucose monomers enable synthesis of the smallest cyclodextrins | |
Ikuta, Daiki1; Hirata, Yasuaki1; Wakamori, Shinnosuke1; Shimada, Hiroaki1; Tomabechi, Yusuke1,2; Kawasaki, Yuri1; Ikeuchi, Kazutada1,3; Hagimori, Takara1; Matsumoto, Shintaro1; Yamada, Hidetoshi1 | |
2019-05-17 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6441页码:674-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Japan |
英文摘要 | Cyclodextrins (CDs) are cyclic oligomers of alpha-1,4-D-glucopyranoside and are known mainly as hexamers to octamers. The central cavities of CDs can retain small molecules, enabling diverse applications. The smallest members, CD3 and CD4, have ring sizes too small to permit the most stable conformations of glucopyranose and have not been accessible synthetically. In this study, we present methods to chemically synthesize both CD3 and CD4. The main factor in the successful synthesis is the creation of a glucopyranose ring conformationally counterbalanced between equatorial-and axial-rich forms. This suppleness is imparted by a bridge between 0-3 and 0-6 of glucose, which enables the generation of desirable, albeit deformed, conformers when synthesizing the cyclic trimer and tetramer. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000468551000032 |
WOS关键词 | SELECTIVE GLYCOSYLATION ; MOLECULAR-STRUCTURE ; GLYCOSIDATION ; CRYSTAL |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201441 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Kwansei Gakuin Univ, Sch Sci & Technol, 2-1 Gakuen, Sanda 6691337, Japan; 2.Tokai Univ, Sch Engn, Dept Appl Chem, 4-1-1 Kitakaname, Hiratsuka, Kanagawa 2591292, Japan; 3.Hokkaido Univ, Fac Sci, Dept Chem, North 10 West 8, Sapporo, Hokkaido 0600810, Japan |
推荐引用方式 GB/T 7714 | Ikuta, Daiki,Hirata, Yasuaki,Wakamori, Shinnosuke,et al. Conformationally supple glucose monomers enable synthesis of the smallest cyclodextrins[J]. SCIENCE,2019,364(6441):674-+. |
APA | Ikuta, Daiki.,Hirata, Yasuaki.,Wakamori, Shinnosuke.,Shimada, Hiroaki.,Tomabechi, Yusuke.,...&Yamada, Hidetoshi.(2019).Conformationally supple glucose monomers enable synthesis of the smallest cyclodextrins.SCIENCE,364(6441),674-+. |
MLA | Ikuta, Daiki,et al."Conformationally supple glucose monomers enable synthesis of the smallest cyclodextrins".SCIENCE 364.6441(2019):674-+. |
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