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DOI | 10.1126/science.aar7486 |
Damage on plants activates Ca2+-dependent metacaspases for release of immunomodulatory peptides | |
Hander, Tim1; Fernandez-Fernandez, Alvaro D.2,3; Kumpf, Robert P.2,3; Willems, Patrick2,3,4,5; Schatowitz, Hendrik1; Rombaut, Debbie2,3; Staes, An4,5; Nolf, Jonah2,3; Pottie, Robin2,3; Yao, Panfeng2,3; Goncalves, Amanda6; Pavie, Benjamin6; Boller, Thomas1; Gevaert, Kris4,5; Van Breusegem, Frank2,3; Bartels, Sebastian1,7; Stael, Simon2,3,4,5 | |
2019-03-22 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6433页码:1301-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland; Belgium; Germany |
英文摘要 | Physical damage to cells leads to the release of immunomodulatory peptides to elicit a wound defense response in the surrounding tissue. In Arabidopsis thaliana, the plant elicitor peptide 1 (Pep1) is processed from its protein precursor, PRECURSOR OF PEP1 (PROPEP1). We demonstrate that upon damage, both at the tissue and single-cell levels, the cysteine protease METACASPASE4 (MC4) is instantly and spatiotemporally activated by binding high levels of Ca2+ and is necessary and sufficient for Pep1 maturation. Cytosol-localized PROPEP1 and MC4 react only after loss of plasma membrane integrity and prolonged extracellular Ca2+ entry. Our results reveal that a robust mechanism consisting of conserved molecular components links the intracellular and Ca2+-dependent activation of a specific cysteine protease with the maturation of damage-induced wound defense signals. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000462016400043 |
WOS关键词 | ELICITOR PEPTIDES ; ARABIDOPSIS-THALIANA ; ENDOGENOUS PEPTIDE ; CRYSTAL-STRUCTURE ; CELL-DEATH ; RECEPTOR ; SIGNAL ; IMMUNITY ; DEFENSE ; CONTRIBUTES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201026 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Basel, Dept Environm Sci, Zurich Basel Plant Sci Ctr, CH-4056 Basel, Switzerland; 2.Univ Ghent, Dept Plant Biotechnol & Bioinformat, B-9052 Ghent, Belgium; 3.VIB UGent Ctr Plant Syst Biol, B-9052 Ghent, Belgium; 4.Univ Ghent, Dept Biomol Med, B-9000 Ghent, Belgium; 5.VIB UGent Ctr Med Biotechnol, B-9000 Ghent, Belgium; 6.VIB UGent Ctr Inflammat Res IRC, VIB BioImaging Core Gent, B-9052 Ghent, Belgium; 7.Univ Freiburg, Univ Hosp Freiburg, Dept Med 2, Fac Med, D-79106 Freiburg, Germany |
推荐引用方式 GB/T 7714 | Hander, Tim,Fernandez-Fernandez, Alvaro D.,Kumpf, Robert P.,et al. Damage on plants activates Ca2+-dependent metacaspases for release of immunomodulatory peptides[J]. SCIENCE,2019,363(6433):1301-+. |
APA | Hander, Tim.,Fernandez-Fernandez, Alvaro D..,Kumpf, Robert P..,Willems, Patrick.,Schatowitz, Hendrik.,...&Stael, Simon.(2019).Damage on plants activates Ca2+-dependent metacaspases for release of immunomodulatory peptides.SCIENCE,363(6433),1301-+. |
MLA | Hander, Tim,et al."Damage on plants activates Ca2+-dependent metacaspases for release of immunomodulatory peptides".SCIENCE 363.6433(2019):1301-+. |
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