GSTDTAP  > 地球科学
DOI10.1126/science.aav2546
The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans
Holth, Jerrah K.1,2; Fritschi, Sarah K.1,2; Wang, Chanung1,2; Pedersen, Nigel P.3,4; Cirrito, John R.1,2; Mahan, Thomas E.1,2; Finn, Mary Beth1,2; Manis, Melissa1,2; Geerling, Joel C.5; Fuller, Patrick M.6; Lucey, Brendan P.1,2; Holtzman, David M.1,2
2019-02-22
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2019
卷号363期号:6429页码:880-883
文章类型Article
语种英语
国家USA
英文摘要

The sleep-wake cycle regulates interstitial fluid (ISF) and cerebrospinal fluid (CSF) levels of beta-amyloid (A beta) that accumulates in Alzheimer's disease (AD). Furthermore, chronic sleep deprivation (SD) increases A beta plaques. However, tau, not Ab, accumulation appears to drive AD neurodegeneration. We tested whether ISF/CSF tau and tau seeding and spreading were influenced by the sleep-wake cycle and SD. Mouse ISF tau was increased similar to 90% during normal wakefulness versus sleep and similar to 100% during SD. Human CSF tau also increased more than 50% during SD. In a tau seeding-and-spreading model, chronic SD increased tau pathology spreading. Chemogenetically driven wakefulness in mice also significantly increased both ISF A beta and tau. Thus, the sleep-wake cycle regulates ISF tau, and SD increases ISF and CSF tau as well as tau pathology spreading.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000459387100046
WOS关键词MOUSE MODEL ; IN-VIVO ; PATHOLOGY ; TRANSMISSION ; PROPAGATION
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
引用统计
被引频次:433[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/200813
专题地球科学
资源环境科学
气候变化
作者单位1.Washington Univ, Sch Med, Dept Neurol, Hope Ctr Neurol Disorders, St Louis, MO 63110 USA;
2.Washington Univ, Sch Med, Charles F & Joanne Knight Alzheimers Dis Res Ctr, St Louis, MO 63110 USA;
3.Emory Univ, Emory Epilepsy Ctr, Dept Neurol, Atlanta, GA 30322 USA;
4.Emory Univ, Program Neurosci, Atlanta, GA 30322 USA;
5.Univ Iowa Hosp & Clin, Dept Neurol, Iowa City, IA 52242 USA;
6.Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Neurol, Div Sleep Med, Boston, MA 02215 USA
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GB/T 7714
Holth, Jerrah K.,Fritschi, Sarah K.,Wang, Chanung,et al. The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans[J]. SCIENCE,2019,363(6429):880-883.
APA Holth, Jerrah K..,Fritschi, Sarah K..,Wang, Chanung.,Pedersen, Nigel P..,Cirrito, John R..,...&Holtzman, David M..(2019).The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans.SCIENCE,363(6429),880-883.
MLA Holth, Jerrah K.,et al."The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans".SCIENCE 363.6429(2019):880-883.
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