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DOI | 10.1126/science.aav2546 |
The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans | |
Holth, Jerrah K.1,2; Fritschi, Sarah K.1,2; Wang, Chanung1,2; Pedersen, Nigel P.3,4; Cirrito, John R.1,2; Mahan, Thomas E.1,2; Finn, Mary Beth1,2; Manis, Melissa1,2; Geerling, Joel C.5; Fuller, Patrick M.6; Lucey, Brendan P.1,2; Holtzman, David M.1,2 | |
2019-02-22 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6429页码:880-883 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The sleep-wake cycle regulates interstitial fluid (ISF) and cerebrospinal fluid (CSF) levels of beta-amyloid (A beta) that accumulates in Alzheimer's disease (AD). Furthermore, chronic sleep deprivation (SD) increases A beta plaques. However, tau, not Ab, accumulation appears to drive AD neurodegeneration. We tested whether ISF/CSF tau and tau seeding and spreading were influenced by the sleep-wake cycle and SD. Mouse ISF tau was increased similar to 90% during normal wakefulness versus sleep and similar to 100% during SD. Human CSF tau also increased more than 50% during SD. In a tau seeding-and-spreading model, chronic SD increased tau pathology spreading. Chemogenetically driven wakefulness in mice also significantly increased both ISF A beta and tau. Thus, the sleep-wake cycle regulates ISF tau, and SD increases ISF and CSF tau as well as tau pathology spreading. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000459387100046 |
WOS关键词 | MOUSE MODEL ; IN-VIVO ; PATHOLOGY ; TRANSMISSION ; PROPAGATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200813 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Washington Univ, Sch Med, Dept Neurol, Hope Ctr Neurol Disorders, St Louis, MO 63110 USA; 2.Washington Univ, Sch Med, Charles F & Joanne Knight Alzheimers Dis Res Ctr, St Louis, MO 63110 USA; 3.Emory Univ, Emory Epilepsy Ctr, Dept Neurol, Atlanta, GA 30322 USA; 4.Emory Univ, Program Neurosci, Atlanta, GA 30322 USA; 5.Univ Iowa Hosp & Clin, Dept Neurol, Iowa City, IA 52242 USA; 6.Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Neurol, Div Sleep Med, Boston, MA 02215 USA |
推荐引用方式 GB/T 7714 | Holth, Jerrah K.,Fritschi, Sarah K.,Wang, Chanung,et al. The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans[J]. SCIENCE,2019,363(6429):880-883. |
APA | Holth, Jerrah K..,Fritschi, Sarah K..,Wang, Chanung.,Pedersen, Nigel P..,Cirrito, John R..,...&Holtzman, David M..(2019).The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans.SCIENCE,363(6429),880-883. |
MLA | Holth, Jerrah K.,et al."The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans".SCIENCE 363.6429(2019):880-883. |
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