Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region

doi:10.1126/science.aav6618

GSTDTAP > 地球科学

DOI	10.1126/science.aav6618
	Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region
	Rodriguez-Barraquer, Isabel 1; Costa, Federico 2,3,4; Nascimento, Eduardo J. M.5; Nery Junior, Nivison 2,3; Castanha, Priscila M. S.6,7; Sacramento, Gielson Almeida 3; Cruz, Jaqueline 3; Carvalho, Mayara 3; De Olivera, Daiana 3; Hagan, Jose E.3,4; Adhikarla, Haritha 4; Wunder, Elsio A., Jr.3,4; Coelho, Danilo F.6,8; Azar, Sasha R.9; Rossi, Shannan L.10; Vasilakis, Nikos 11; Weaver, Scott C.10; Ribeiro, Guilherme S.2,3,12; Balmaseda, Angel 13,14; Harris, Eva 15; Nogueira, Mauricio L.16; Reis, Mitermayer G.3,4,12; Marques, Ernesto T. A.5,6,17; Cummings, Derek A. T.18,19; Ko, Albert I.3,4
	2019-02-08
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2019
卷号	363 期号:6427 页码:607-+
文章类型	Article
语种	英语
国家	USA; Brazil; Nicaragua
英文摘要	The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73% of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associated with reduced risk of ZIKV infection and symptoms. The landscape of ZIKV immunity that now exists may affect the risk for future transmission.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000458114200043
WOS关键词	INFECTION ; ANTIBODY ; ENHANCEMENT ; OUTBREAK ; SALVADOR
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/200706
专题	地球科学资源环境科学气候变化
作者单位	1.Univ Calif San Francisco, Dept Med, San Francisco, CA USA; 2.Univ Fed Bahia, Inst Saude Colet, Salvador, BA, Brazil; 3.Fundacao Oswaldo Cruz MS, Inst Goncalo Moniz, Salvador, BA, Brazil; 4.Yale Sch Publ Hlth, Dept Epidemiol Microbial Dis, New Haven, CT 06510 USA; 5.Univ Pittsburgh, Dept Infect Dis & Microbiol, Pittsburgh, PA USA; 6.Fundacao Oswaldo Cruz MS, Inst Aggeu Magalhaes, Recife, PE, Brazil; 7.Univ Pernambuco, Fac Ciencias Med, Recife, PE, Brazil; 8.Univ Fed Pernambuco, Dept Fundamental Chem, BR-50740540 Recife, PE, Brazil; 9.Univ Texas Med Branch, Inst Translat Sci, Galveston, TX 77555 USA; 10.Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA; 11.Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA; 12.Univ Fed Bahia, Fac Med, Salvador, BA, Brazil; 13.Sustainable Sci Inst, Managua, Nicaragua; 14.Minist Hlth, Ctr Nacl Diagnost Referencia, Lab Nacl Virol, Managua, Nicaragua; 15.Univ Calif Berkeley, Sch Publ Hlth, Div Infect Dis & Vaccinol, Berkeley, CA 94720 USA; 16.Fac Med Sao Jose do Rio Preto, Sao Paulo, Brazil; 17.Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA; 18.Univ Florida, Dept Biol, Gainesville, FL 32611 USA; 19.Univ Florida, Emerging Pathogens Inst, Gainesville, FL 32611 USA
推荐引用方式 GB/T 7714	Rodriguez-Barraquer, Isabel,Costa, Federico,Nascimento, Eduardo J. M.,et al. Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region[J]. SCIENCE,2019,363(6427):607-+.
APA	Rodriguez-Barraquer, Isabel.,Costa, Federico.,Nascimento, Eduardo J. M..,Nery Junior, Nivison.,Castanha, Priscila M. S..,...&Ko, Albert I..(2019).Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region.SCIENCE,363(6427),607-+.
MLA	Rodriguez-Barraquer, Isabel,et al."Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region".SCIENCE 363.6427(2019):607-+.