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DOI | 10.1126/science.aat7554 |
Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation | |
Costa Jordao, Marta Joana1,2; Sankowski, Roman1,3; Brendecke, Stefanie M.1,15; Sagar4; Locatelli, Giuseppe5,6; Tai, Yi-Heng5,6; Tay, Tuan Leng1,2,7; Schramm, Eva1; Armbruster, Stephan1; Hagemeyer, Nora1; Gross, Olaf1,8,9,10; Mai, Dominic11,12; Cicek, Ozgun11; Falk, Thorsten8,11; Kerschensteiner, Martin5,6,13; Grun, Dominic4; Prinz, Marco1,8,10,14 | |
2019-01-25 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6425页码:365-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; Norway |
英文摘要 | The innate immune cell compartment is highly diverse in the healthy central nervous system (CNS), including parenchymal and non-parenchymal macrophages. However, this complexity is increased in inflammatory settings by the recruitment of circulating myeloid cells. It is unclear which disease-specific myeloid subsets exist and what their transcriptional profiles and dynamics during CNS pathology are. Combining deep single-cell transcriptome analysis, fate mapping, in vivo imaging, clonal analysis, and transgenic mouse lines, we comprehensively characterized unappreciated myeloid subsets in several CNS compartments during neuroinflammation. During inflammation, CNS macrophage subsets undergo self-renewal, and random proliferation shifts toward clonal expansion. Last, functional studies demonstrated that endogenous CNS tissue macrophages are redundant for antigen presentation. Our results highlight myeloid cell diversity and provide insights into the brain's innate immune system. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000456871800030 |
WOS关键词 | CENTRAL-NERVOUS-SYSTEM ; DENDRITIC CELLS ; MULTIPLE-SCLEROSIS ; GENE-EXPRESSION ; MICROGLIA ; CNS ; MONOCYTES ; MOUSE ; MACROPHAGES ; REVEALS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200616 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Freiburg, Inst Neuropathol, Fac Med, Freiburg, Germany; 2.Univ Freiburg, Fac Biol, Freiburg, Germany; 3.Univ Freiberg, Fac Med, Berta Ottenstein Programme, Freiberg, Germany; 4.Max Planck Inst Immunobiol & Epigenet, Freiburg, Germany; 5.Ludwig Maximilians Univ Munchen, Univ Hosp, Inst Clin Neuroimmunol, Munich, Germany; 6.Ludwig Maximilians Univ Munchen, Fac Med, Biomed Ctr BMC, Munich, Germany; 7.Univ Freiburg, Cluster Excellence BrainLinks BrainTools, Freiburg, Germany; 8.Univ Freiburg, BIOSS Ctr Biol Signalling Studies, Freiburg, Germany; 9.Tech Univ Munich, Sch Med, Univ Hosp Rechts Isar, Inst Clin Chem & Pathobiochem, Munich, Germany; 10.Univ Freiburg, CIBSS Ctr Integrat Biol Signalling Studies, Freiburg, Germany; 11.Univ Freiburg, Inst Comp Sci, Freiburg, Germany; 12.Albert Ludwigs Univ, Life Imaging Ctr, Ctr Biol Syst Anal, Freiburg, Germany; 13.Munich Cluster Syst Neurol SyNergy, Munich, Germany; 14.Univ Freiburg, Ctr NeuroModulat, Freiburg, Germany; 15.Oslo Univ Hosp, Dept Pathol, Oslo, Norway |
推荐引用方式 GB/T 7714 | Costa Jordao, Marta Joana,Sankowski, Roman,Brendecke, Stefanie M.,et al. Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation[J]. SCIENCE,2019,363(6425):365-+. |
APA | Costa Jordao, Marta Joana.,Sankowski, Roman.,Brendecke, Stefanie M..,Sagar.,Locatelli, Giuseppe.,...&Prinz, Marco.(2019).Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation.SCIENCE,363(6425),365-+. |
MLA | Costa Jordao, Marta Joana,et al."Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation".SCIENCE 363.6425(2019):365-+. |
条目包含的文件 | 条目无相关文件。 |
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