Secreted amyloid-beta precursor protein functions as a GABA(B)R1a ligand to modulate synaptic transmission

doi:10.1126/science.aao4827

GSTDTAP > 地球科学

DOI	10.1126/science.aao4827
	Secreted amyloid-beta precursor protein functions as a GABA(B)R1a ligand to modulate synaptic transmission
	Rice, Heather C.1,2; de Malmazet, Daniel 3,4; Schreurs, An 5; Frere, Samuel 6,7; Van Molle, Inge 8; Volkov, Alexander N.8,9; Creemers, Eline 1,2; Vertkin, Irena 6,7; Nys, Julie 1,2; Ranaivoson, Fanomezana M.10,16; Comoletti, Davide 10,11,17; Savas, Jeffrey N.12; Remaut, Han 8; Balschun, Detlef 5; Wierda, Keimpe D.1,2; Slutsky, Inna 6,7; Farrow, Karl 3,4,13,14; De Strooper, Bart 1,2,15; de Wit, Joris 1,2
	2019-01-11
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2019
卷号	363 期号:6423 页码:143-143
文章类型	Article
语种	英语
国家	Belgium; Israel; USA; England; France; New Zealand
英文摘要	Amyloid-beta precursor protein (APP) is central to the pathogenesis of Alzheimer's disease, yet its physiological function remains unresolved. Accumulating evidence suggests that APP has a synaptic function mediated by an unidentified receptor for secreted APP (sAPP). Here we show that the sAPP extension domain directly bound the sushi 1 domain specific to the gamma-aminobutyric acid type B receptor subunit 1a (GABA(B)R1a). sAPP-GABA(B)R1a binding suppressed synaptic transmission and enhanced short-term facilitation in mouse hippocampal synapses via inhibition of synaptic vesicle release. A 17-amino acid peptide corresponding to the GABA(B)R1a binding region within APP suppressed in vivo spontaneous neuronal activity in the hippocampus of anesthetized Thy1-GCaMP6s mice. Our findings identify GABA(B)R1a as a synaptic receptor for sAPP and reveal a physiological role for sAPP in regulating GABA(B)R1a function to modulate synaptic transmission.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000455320600040
WOS关键词	LONG-TERM POTENTIATION ; PHYSIOLOGICAL FUNCTIONS ; PRESYNAPTIC INHIBITION ; RECEPTOR ANTAGONIST ; MOLECULAR-STRUCTURE ; NEURONAL-ACTIVITY ; MICE LACKING ; APPS-ALPHA ; REVEALS ; RELEASE
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/200517
专题	地球科学资源环境科学气候变化
作者单位	1.VIB Ctr Brain & Dis Res, Leuven, Belgium; 2.Katholieke Univ Leuven, Leuven Brain Inst, Dept Neurosci, Leuven, Belgium; 3.Neuroelect Res Flanders, Leuven, Belgium; 4.Katholieke Univ Leuven, Leuven Brain Inst, Dept Biol, Leuven, Belgium; 5.Katholieke Univ Leuven, Brain & Cognit, Leuven, Belgium; 6.Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, Tel Aviv, Israel; 7.Tel Aviv Univ, Sagol Sch Neurosci, Tel Aviv, Israel; 8.VIB VUB, Struct Biol Res Ctr, Brussels, Belgium; 9.VUB, Jean Jeener NMR Ctr, Brussels, Belgium; 10.Rutgers State Univ, Robert Wood Johnson Med Sch, Child Hlth Inst New Jersey, New Brunswick, NJ USA; 11.Rutgers State Univ, Dept Neurosci & Cell Biol, Robert Wood Johnson Med Sch, New Brunswick, NJ USA; 12.Northwestern Univ, Feinberg Sch Med, Dept Neurol, Chicago, IL 60611 USA; 13.VIB, Leuven, Belgium; 14.Imec, Leuven, Belgium; 15.UCL, UK Dementia Res Inst, London, England; 16.PSL Res Univ, CNRS, UMR 144, Struct Motil,Inst Curie, Paris, France; 17.Victoria Univ Wellington, Sch Biol Sci, Wellington, New Zealand
推荐引用方式 GB/T 7714	Rice, Heather C.,de Malmazet, Daniel,Schreurs, An,et al. Secreted amyloid-beta precursor protein functions as a GABA(B)R1a ligand to modulate synaptic transmission[J]. SCIENCE,2019,363(6423):143-143.
APA	Rice, Heather C..,de Malmazet, Daniel.,Schreurs, An.,Frere, Samuel.,Van Molle, Inge.,...&de Wit, Joris.(2019).Secreted amyloid-beta precursor protein functions as a GABA(B)R1a ligand to modulate synaptic transmission.SCIENCE,363(6423),143-143.
MLA	Rice, Heather C.,et al."Secreted amyloid-beta precursor protein functions as a GABA(B)R1a ligand to modulate synaptic transmission".SCIENCE 363.6423(2019):143-143.